N-(3-OXOOCTANOYL)-L-HOMOSERINE LACTONE Struktur

N-(3-OXOOCTANOYL)-L-HOMOSERINE LACTONE

Bezeichnung:N-(3-OXOOCTANOYL)-L-HOMOSERINE LACTONE

CAS-Nr147795-39-9

Englisch Name:N-(3-OXOOCTANOYL)-L-HOMOSERINE LACTONE

CBNumberCB1504055

SummenformelC12H19NO4

Molgewicht241.28

MOL-Datei147795-39-9.mol

N-(3-OXOOCTANOYL)-L-HOMOSERINE LACTONE physikalisch-chemischer Eigenschaften

Schmelzpunkt	54-60 °C
Siedepunkt	490.1±45.0 °C(Predicted)
Dichte	1.12±0.1 g/cm3(Predicted)
storage temp.	-20°C
Löslichkeit	chloroform: 50 mg/mL, clear, colorless
Aggregatzustand	white powder
pka	11.09±0.46(Predicted)
Farbe	White to off-white

Sicherheit

WGK Germany

N-(3-OXOOCTANOYL)-L-HOMOSERINE LACTONE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which generally consists of a fatty acid coupled with homoserine lactone (HSL). Regulation of bacterial quorum sensing signaling systems to inhibit pathogenesis represents a new approach to antimicrobial therapy in the treatment of infectious diseases. AHLs vary in acyl group length (C₄-C₁₈), in the substitution of C3 (hydrogen, hydroxyl, or oxo group), and in the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signal specificity through the affinity of transcriptional regulators of the LuxR family. In the gram-negative bacterium A. tumefaciens, N-3-oxo-octanoyl-L-homoserine lactone promotes the expression of the transcriptional activator (and LuxR homolog) TraR.
Verwenden
N-3-oxo-octanoyl-L-Homoserine lactone is a reagent that promotes the expression of the transcriptional activator.
Verwenden
N-(3-Oxooctanoyl)-L-homoserine lactone has been used to study the effects of pH, temperature and salinity on extracellular polymeric substances (EPS) of Pseudomonas aeruginosa biofilm.
Allgemeine Beschreibung
N-(3-Oxooctanoyl)-L-homoserine lactone is a common quorum sensing (QS) signal.
Biochem/physiol Actions
N-(3-Oxooctanoyl)-L-homoserine lactone stimulates the tra gene expression. It is an autoinducer and potent antagonist.

N-(3-OXOOCTANOYL)-L-HOMOSERINE LACTONE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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