Oxycodonhydrochlorid

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H336：Kann Schläfrigkeit und Benommenheit verursachen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P270：Bei Gebrauch nicht essen, trinken oder rauchen.

  P271：Nur im Freien oder in gut belüfteten Räumen verwenden.

  P301+P312：BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

OXYCODONE HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R22:Gesundheitsschädlich beim Verschlucken.

• S-Sätze Betriebsanweisung:

  S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).

• Beschreibung

  Oxycodone (hydrochloride) (Item No. 26513) is an analytical reference standard categorized as an opioid. Oxycodone is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.

• Chemische Eigenschaften

  White Solid

• Originator

  Oxyfast,Purdue Pharma, L.P.

• Verwenden

  Controlled substance (opiate). Analgesic (narcotic)

• Definition

  ChEBI: Oxycodone hydrochloride is a hydrochloride obtained by reaction of oxycodone with one molar equivalent of hydrochloric acid. It is a moderately potent opioid analgesic, generally used for relief of moderate to severe pain. It has a role as a mu-opioid receptor agonist, an antitussive and an opioid analgesic. It contains an oxycodone(1+).

• Trademarks

  Oxycontin (Purdue); Roxicodone (Roxane); Roxicodone (Xanodyne).

• Therapeutic Function

  Narcotic analgesic

• Biologische Aktivität

  Potent and selective μ -opioid receptor agonist (K i values are 16 and >1000 nM for hMOR1 and hKOR1 respectively).

• Clinical Use

  Oxycodone is about equipotent with morphine, but because of the 3-OCH group, it has a much lower oral:parenteral dose ratio. Thus, oxycodone is used orally to treat severe to moderate pain. It is a drug as a single agent and when combined in strong analgesic mixtures. Oxycodone has a plasma half-life of approximately 4 hours and requires dosing every 4 to 6 hours.

• Arzneimittelwechselwirkung

  Potentially hazardous interactions with other drugs
  Analgesics: possible opioid withdrawal with buprenorphine and pentazocine.
  Antibacterials: metabolism possibly increased by rifampicin; metabolism inhibited by telithromycin.
  Antidepressants: CNS excitation or depression with MAOIs - avoid; possible CNS excitation or depression with moclobemide; increased sedative effects with tricyclics.
  Antifungals: concentration increased by voriconazole.
  Antihistamines: increased sedative effects with sedating antihistamines.
  Antipsychotics: enhanced hypotensive and sedative effects.
  Antivirals: concentration possibly increased by ritonavir.
  Dopaminergics: avoid with selegiline.
  Nalmefene: avoid concomitant use.
  Sodium oxybate: enhanced effect of sodium oxybate - avoid.

• Stoffwechsel

  Oxycodone is metabolised in the liver to produce noroxycodone via the CYP3A system, oxymorphone via the CYP2D6 system and various conjugated glucuronides.
  The analgesic effects of the metabolites are clinically insignificant. Both metabolites undergo glucuronidation and are excreted with unchanged drug in urine.

OXYCODONE HYDROCHLORIDE Upstream-Materialien And Downstream Produkte

124-90-3, OXYCODONE HYDROCHLORIDE Verwandte Suche: