Isonicotinsure

Bezeichnung:Isonicotinsure

CAS-Nr55-22-1

Englisch Name:Isonicotinic acid

CBNumberCB1462924

SummenformelC6H5NO2

Molgewicht123.11

MOL-Datei55-22-1.mol

Synonyma

Isonicotinsure

Isonicotinsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	≥300 °C (lit.)
Siedepunkt	260 °C (15 mmHg)
Dichte	1,47g/cm
Brechungsindex	1.5423 (estimate)
Flammpunkt	260°C/15mm
storage temp.	no restrictions.
Löslichkeit	6g/l
pka	4.96(at 25℃)
Aggregatzustand	powder
Farbe	yellow to tan
PH	3-4 (6g/l, H2O, 20℃)(saturated solution)
Wasserlöslichkeit	5.2 g/L (20 ºC)
Merck	14,5187
BRN	109599
InChIKey	TWBYWOBDOCUKOW-UHFFFAOYSA-N
CAS Datenbank	55-22-1(CAS DataBase Reference)
NIST chemische Informationen	Isonicotinic acid(55-22-1)
EPA chemische Informationen	Isonicotinic acid (55-22-1)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	2
RTECS-Nr.	NS1103000
TSCA	Yes
HS Code	29333999
Toxizität	LD50 orally in Rabbit: 5000 mg/kg

Gefahreninformationscode (GHS)

Isonicotinic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
isonicotinic acid is also known as pyridine-4-carboxylic acid. white to light yellow crystal powder or white needle crystals. odorless, sublimable. molecular weight 123.11. melting point 319°C . slightly soluble in cold water, soluble in hot water, insoluble in alcohol, benzene and ether. isonicotinic acid is an amphoteric compound that is soluble in both acids and bases. soluble in hot water and ethanol, slightly soluble in cold water and ether. stable to heat and oxidation.
Verwenden
Isonicotinic acid is a metabolite of isoniazid. It is an isomer of nicotinic acid. The chronic toxicity of isonicotinic acid is slightly higher than that of isonicotinic acid hydrazide ( INH ) .
Isonicotinic acid is a moderately basic compound (based on its pKa). Isonicotinic acid is an organic compound with a carboxyl group on a pyridine ring. The carboxyl group for isonicotinic acid is on the 4-position instead of the 3-position for nicotinic acid. It is an isomer of nicotinic acid. Isonicotinic acid is a metabolite of isoniazid.
Isonicotinic acid considered to be inactive isomer of nicotinic acid. Isonicotinic acid is a metabolite of pyridine-4-carboxy hydrazide (isonicotinyl hydrazide; isoniazid) a front-line weapon in the battle against tuberculosis. Isonicotinic acid and its derivatives are used in manufacturing pharmaceuticals and agrochemicals.
Used in the biological study of differentiation induced by nicotinic acid, nicotinamide and isonicotinic acid in human leukemia cell lines
Definition
ChEBI: Isonicotinic acid is a pyridinemonocarboxylic acid in which the carboxy group is at position 4 of the pyridine ring. It has a role as a human metabolite and an algal metabolite. It is a conjugate acid of an isonicotinate.
synthetische
Isonicotinic acid is synthesized by continuous oxidation with 4-methylpyridine as raw material and vanadium pentoxide as catalyst. The purity of the industrial product isonicotinic acid is more than 95%, and the yield of the above method is 70-75%. The consumption of 4-methylpyridine per ton of product is 1070kg.
Application
Isonicotinic acid (IN) can be used as:
An organocatalyst in the one pot four component condensation reaction, to synthesize pyranopyrazoles based heterocyclic compounds.
An organic ligand for the preparation of copper(I) halide coordination polymer [CuBr(IN)]n, by hydrothermal method.
As a starting material for the synthesis of cation-dimers with potent antimalarial activity.
läuterung methode
Crystallise the acid repeatedly from water and dry it under vacuum at 110o or sublime it at 260o/15mm (m 319o). [Beilstein 22 III/IV 518, 22/2 V 188.]

Isonicotinic acid Upstream-Materialien And Downstream Produkte

Isonicotinsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

55-22-1, Isonicotinic acid Verwandte Suche:

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