1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE Struktur

1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE

Bezeichnung:1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE

CAS-Nr25371-96-4

Englisch Name:1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE

CBNumberCB1457890

SummenformelC10H7F3N2

Molgewicht212.17

MOL-Datei25371-96-4.mol

1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE physikalisch-chemischer Eigenschaften

Schmelzpunkt	43 °C
Siedepunkt	75°C 0,02mm
Dichte	1.3253 (estimate)
Flammpunkt	75°C/0.025mm
storage temp.	2-8°C
Löslichkeit	Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 20 mg/ml).
Aggregatzustand	White solid.
pka	4.96±0.10(Predicted)
Farbe	White
Sensitive	Light Sensitive
BRN	3955637
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
CAS Datenbank	25371-96-4(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
Hazard Note	Irritant
HazardClass	IRRITANT, LIGHT SENSITIVE
HS Code	29339900

Gefahreninformationscode (GHS)

1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
TRIM (25371-96-4) is a potent inhibitor of neuronal and inducible nitric oxide synthases, (IC50?= 28.2 and 27.0 μM respectively). Inhibits endothelial NOS with lower potency (IC50 = 1057.5 μM).1?TRIM displays antinociceptive activity?in vivo.2
Verwenden
TRIM is a potent inhibitor of neuronal nitric oxide synthase in vitro, in animal models.
Definition
ChEBI: 1-[2-(trifluoromethyl)phenyl]imidazole is a member of imidazoles.
Biologische Aktivität
A potent inhibitor of neuronal and inducible NO synthases, with much lower affinity for the endothelial isoform (displays IC 50 values of 28.2, 27.0 and 1057.5 μ M respectively). Antinociceptive in vivo .
Biochem/physiol Actions
Potent nitric oxide synthase inhibitor. Because of the putative involvement of nitric oxide in depression and stress syndromes, TRIM was studied for its antidepressant effects, and found to reduce manifestations of stress in an animal model as well as fluoxetine.
Einzelnachweise
1) Handy?et al. (1995), The antinociceptive effect of 1-(2-trifluoromethylphenyl)imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse; Br. J. Pharmacol.,?116?2349 2) Handy?et al. (1996),?Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects; Br. J. Pharmacol.,?119?423

1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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