6,7-Dihydroxy-2-benzopyron

Bezeichnung:6,7-Dihydroxy-2-benzopyron

CAS-Nr305-01-1

Englisch Name:Esculetin

CBNumberCB1456020

SummenformelC9H6O4

Molgewicht178.14

MOL-Datei305-01-1.mol

Synonyma

6,7-Dihydroxy-2-benzopyron

6,7-Dihydroxy-2-benzopyron physikalisch-chemischer Eigenschaften

Schmelzpunkt	271-273 °C(lit.)
Siedepunkt	270.35°C (rough estimate)
Dichte	1.3431 (rough estimate)
Brechungsindex	1.4500 (estimate)
storage temp.	2-8°C
Löslichkeit	Solubility Almost insoluble in boiling water, ether; soluble in hot ethanol, glacial acetic acid
Aggregatzustand	powder
pka	1.71(at 25℃)
Farbe	Light yellow
Säure-Base-Indikators(pH-Indikatoren)	Weak blue uorescence (1.5) to strong blue uorescence (2.0)
Wasserlöslichkeit	slightly soluble
Merck	14,3697
BRN	152788
Major Application	antiinflammatory, Herbicides, cosmetics, teeth whitening agent, antifungal, neurodegenerative andfungal, antibacterial, antiviral, treating drug-induced weight gain, neurodegenerative and blood coagulation disorders, cancer, amyloidosis, skin impairments and baldness
InChIKey	ILEDWLMCKZNDJK-UHFFFAOYSA-N
LogP	0.980 (est)
CAS Datenbank	305-01-1(CAS DataBase Reference)
NIST chemische Informationen	Coumarin, 6,7-dihydroxy-(305-01-1)
EPA chemische Informationen	Esculetin (305-01-1)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36-37/39
WGK Germany	3
RTECS-Nr.	GN6382500
HS Code	29322090

Gefahreninformationscode (GHS)

Esculetin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
YELLOWISH CRYSTALLINE POWDER
Verwenden
In filters for absorption of ultraviolet light.
Verwenden
antifungal, hepatoprotective, IL-1 inhibitor
Verwenden
In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.
Definition
ChEBI: A hydroxycoumarin that is umbelliferone in which the hydrogen at position 6 is substituted by a hydroxy group. It is used in filters for absorption of ultraviolet light.
Allgemeine Beschreibung
Esculetin is a derivative of coumarin, found in various plant species including Cichorium intybus (chicory), Bougainvillea spectabilis, Artemisia capillaris, etc and leaves of Citrus limonia (Rutaceae), Ceratostigma willmottianum, etc. It exhibits multiple pharmacological activities and is found to be a potent inhibitor of cyclooxygenase, 5-lipoxygenase, 12-lipoxygenase, catechol-O-methyl transferase, NADPH oxidase and xanthine oxidase enzymes.
läuterung methode
It forms prisms from AcOH, aqueous EtOH or aqueous MeOH, and provides leaflets on sublimation in a vacuum. [Kagan J Am Chem Soc 88 2617 1966, Marby et al. Phytochemistry 4 492 1965.] Esculin (the 6-glucoside) has m 215o(dec), [] D -41o (c 5, pyridine). [Beilstein 18 III/IV 1322, 18/3 V 202.]

Esculetin Upstream-Materialien And Downstream Produkte

6,7-Dihydroxy-2-benzopyron Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

305-01-1, Esculetin Verwandte Suche:

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