Pseudoephedrinhydrochlorid

Bezeichnung:Pseudoephedrinhydrochlorid

CAS-Nr345-78-8

Englisch Name:(1S,2S)-(+)-Pseudoephedrine hydrochloride

CBNumberCB1399716

SummenformelC10H16ClNO

Molgewicht201.69

MOL-Datei345-78-8.mol

Synonyma

Pseudoephedrinhydrochlorid

Pseudoephedrinhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	185-188 °C(lit.)
alpha	61 º (c=5, H2O,2dm tube)
storage temp.	Refrigerator (+4°C)
Löslichkeit	Freely soluble in water and in ethanol (96 per cent), sparingly soluble in methylene chloride.
pka	9.22(at 25℃)
Aggregatzustand	buffered aqueous solution
Biologische Quelle	rabbit
Merck	13,8007
BRN	3915112
LogP	-1.74 at 23℃ and pH7
CAS Datenbank	345-78-8(CAS DataBase Reference)
EPA chemische Informationen	Benzenemethanol, .alpha.-[(1S)-1-(methylamino)ethyl]-, hydrochloride, (.alpha.S)- (345-78-8)

Sicherheit

Kennzeichnung gefährlicher	Xn,T,F
R-Sätze:	22-36/37/38-36/38-39/23/24/25-23/24/25-11
S-Sätze:	26-36-24/25-45-36/37-16-7
RIDADR	1544
WGK Germany	3
RTECS-Nr.	UL5950000
HazardClass	6.1(b)
PackingGroup	III
HS Code	29394200
Toxizität	LD50 i.p. in mice: 1.0 mmole/kg (Fairchild, Alles)

Gefahreninformationscode (GHS)

(1S,2S)-(+)-Pseudoephedrine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
white powder
Verwenden
Non-selective adrenergic agonist; decongestant (nasal). Controlled precursor.
Definition
ChEBI: A hydrochloride that is the monohydrochloride salt of pseudoephedrine.
Trademarks
Efidac (ALZA); Novafed (Sanofi Aventis); Sudafed (GlaxoSmithKline); Sudafed (Warner Lambert).
Biologische Aktivität
Trefoil factor 1 is a protein encoded by the TFF1 gene in humans. The proteins are small secretory proteins characterized by three intra-chain disulfide bonds forming the trefoil motif or P-domain. It is abundantly expressed on mucosal surfaces and especially within the gastrointestinal tract. The protein belongs to highly conserved proteins th at play an essential role in epithelial regeneration within the gastrointestinal tract. Its expression is strongly induced after mucosal injury and may function as a gastric tumor suppressor gene. It is expressed in various types of carcinomas including breast cancer. The gene contains an estrogen response element and its expression can be regulated by estrogen. Increased expression of this gene is found to be associated with tumor progression in some tumors and missense mutations in the gene have been detected in gastric cancer.
Kontakt-Allergie
This sympathomimetic a-adrenergic agonist is found in plants of the genus Ephedra (Ephedraceae) and is systemically used as a nasal decongestant. It can induce drug skin reactions such as acute generalized exanthematic pustulosis or generalized eczema.
Clinical Use
Nasal decongestant
Arzneimittelwechselwirkung
Potentially hazardous interactions with other drugs
Adrenergic neurone blockers: antagonise hypotensive effect of adrenergic neurone blockers.
Anaesthetics: increased risk of ventricular arrhythmias with isoflurane.
Antibacterials: risk of hypertensive crisis with linezolid.
Antidepressants: risk of hypertensive crisis with MAOIs and moclobemide.
Dopaminergics: avoid concomitant use with selegiline and rasagiline.
Stoffwechsel
A small amount of pseudoephedrine is hepatically metabolised by N-demethylation.
It is excreted largely unchanged in the urine with small amounts of its hepatic metabolite.
läuterung methode
1S,2S-Pseudoephedrine hydrochloride [345-78-8] M 210.7, m 181-182o, 185-188o, [ + 6 1o (c 1 H2O). Crystallise the salt from EtOH. [Beilstein 13 IV 1878.]

345-78-8, (1S,2S)-(+)-Pseudoephedrine hydrochloride Verwandte Suche:

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