S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben). S24/25:Berührung mit den Augen und der Haut vermeiden.
Verwenden
Anti-l-Afadin antibody produced in rabbit has been used in:
western blotting
immunofluorescence experiments
immunocytochemistry
immunohistochemistry
Allgemeine Beschreibung
Afadin is a multidomain protein that binds F-actin and E-catenin proteins at cell-cell adheren junctions. I-afadin is a ubiquitously expressed splice variant of afadin that contains PDZ and F-actin binding domains at the C-terminal end. I-afadin is homologous to the human AF-6 protein .
Biochem/physiol Actions
AF-6/Afadin regulates the formation of tight and adherens junctions in the cell and its absence in mice leads to embryonic defects and lethality?. Afadin is implicated in primary breast cancer and pancreatic cancer. It downregulates the process of migration and metastasis in cancer cells.
