7,12-Dimethyl-benz(a)anthracen

Bezeichnung:7,12-Dimethyl-benz(a)anthracen

CAS-Nr57-97-6

Englisch Name:7,12-DIMETHYLBENZ[A]ANTHRACENE

CBNumberCB1384824

SummenformelC20H16

Molgewicht256.34

MOL-Datei57-97-6.mol

Synonyma

7,12-Dimethylbenz[a]anthracen

7,12-Dimethyl-benz(a)anthracen

7,12-Dimethyl-benz(a)anthracen physikalisch-chemischer Eigenschaften

Schmelzpunkt	122-123 °C(lit.)
Siedepunkt	183-184 °C765 mm Hg(lit.)
Dichte	0.9 g/mL at 25 °C(lit.)
Brechungsindex	n20/D 1.501(lit.)
Flammpunkt	130 °F
storage temp.	Sealed in dry,Room Temperature
Aggregatzustand	Crystalline Powder
Farbe	Yellow to greenish
Merck	14,3235
BRN	1912135
CAS Datenbank	57-97-6(CAS DataBase Reference)
EPA chemische Informationen	7,12-Dimethylbenz[a]anthracene (57-97-6)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	22-45
S-Sätze:	45-53-36/37
WGK Germany	3
RTECS-Nr.	DP4500000
F	10-13-23
HS Code	29029090
Giftige Stoffe Daten	57-97-6(Hazardous Substances Data)

Gefahreninformationscode (GHS)

7,12-DIMETHYLBENZ[A]ANTHRACENE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R45:Kann Krebs erzeugen.
R22:Gesundheitsschädlich beim Verschlucken.
R67:Dämpfe können Schläfrigkeit und Benommenheit verursachen.
R65:Gesundheitsschädlich: kann beim Verschlucken Lungenschäden verursachen.
R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
R38:Reizt die Haut.
R11:Leichtentzündlich.
R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S62:Bei Verschlucken kein Erbrechen herbeiführen. Sofort ärztlichen Rat einholen und Verpackung oder dieses Etikett vorzeigen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
Beschreibung
DBA is a greenish-yellow solid. Polynucleararomatic hydrocarbons (PAHs) are compounds containingmultiple benzene rings and are also called polycyclic aromatic hydrocarbons. Molecular weight= 256.36; Freezing/Melting point= 122℃. Insoluble in water
Chemische Eigenschaften
Yellow Powder
Verwenden
7,12-Dimethylbenz[a]anthracene was used:
- to study the effects of Cimicifuga racemosa (CR) extract on the growth of mammary tumor induced by 7,12-Dimethylbenz[a]anthracene
- in the study to compare the anti-carcinogenic properties of four red wine polyphenols as an initiator to cause skin cancer in CD-1 mouse model
- to induce epithelial carcinogenicity in order to study the apoptotic, proliferating and p12^doc-1 profiles of normal, hyperplastic, dysplastic and malignant oral epithelium in the cheek pouch of the Syrian hamster
- to cause mammary tumors to examine the causes and prevention of triacylglycerol accumulation in rat liver due to tamoxifen
Verwenden
A highly potent carcinogen that is activated by microsomal enzymes to a diol epoxide metabolite that binds covalently to DNA in mammalian cells, leading ultimately to tumor induction
Definition
ChEBI: A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.
Synthesis Reference(s)
The Journal of Organic Chemistry, 36, p. 966, 1971 DOI: 10.1021/jo00806a023
Allgemeine Beschreibung
Yellow to greenish-yellow crystals or a yellow solid. Odorless. Maximum fluorescence at 440 nm. Bluish-violet fluorescence in UV light.
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
7,12-DIMETHYLBENZ[A]ANTHRACENE is incompatible with strong oxidizing agents .
Brandgefahr
7,12-DIMETHYLBENZ[A]ANTHRACENE is combustible.
Biochem/physiol Actions
7,12-Dimethylbenz[a]anthracene has been found to be cytotoxic in nature, having carcinogenic properties. It also shows selective necrosis and hemorrhaging in the adrenal gland along with an inhibitory effect on plasma alkaline phosphatase levels. Its damaging effects are due to its ability to form charge transfer complexes by donating electrons to appropriate electron acceptors.
Sicherheitsprofil
Suspected carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. A transplacental carcinogen. Poison by ingestion, intravenous, subcutaneous, intraperitoneal, and intratracheal routes. Other experimental reproductive effects. Human mutation data reported. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
mögliche Exposition
Oxidizing agents
Erste Hilfe
If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. If thischemical contacts the skin, remove contaminated clothingand wash immediately with soap and water. If this chemicalhas been inhaled, remove from exposure, begin rescuebreathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart actionhas stopped. Transfer promptly to a medical facility
Lager
Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with DBA youshould be trained on its proper handling and storage. Storein tightly closed containers in a cool, well-ventilated areaaway from oxidizers. A regulated, marked area should beestablished where this chemical is handled, used, or storedin compliance with OSHA Standard 1910.1045.
Versand/Shipping
The name of this material is not in the DOT listof materials for label and packaging standards. However,based on regulations, it may be classified as anEnvironmentally hazardous substances, solid, n.o.s. Thischemical requires a shipping label of “CLASS 9.” It falls inHazard Class 9 and Packing Group III.[20,21
läuterung methode
Purify DMBA by chromatography on alumina/toluene or *benzene. Crystallise it from acetone/EtOH. [Beilstein 5 IV 2587.]
Inkompatibilitäten
Contact can irritate and burn theskin and eyes. Irritates the respiratory tract. High exposuremay damage the blood cells, causing anemia

7,12-DIMETHYLBENZ[A]ANTHRACENE Upstream-Materialien And Downstream Produkte

7,12-Dimethyl-benz(a)anthracen Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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