(R,S)-ANATABINE Struktur

(R,S)-ANATABINE

Bezeichnung:(R,S)-ANATABINE

CAS-Nr2743-90-0

Englisch Name:(R,S)-ANATABINE

CBNumberCB1382628

SummenformelC10H12N2

Molgewicht160.22

MOL-Datei2743-90-0.mol

(R,S)-ANATABINE physikalisch-chemischer Eigenschaften

Siedepunkt	136
Dichte	1.045±0.06 g/cm3(Predicted)
storage temp.	Amber Vial, Refrigerator, Under Inert Atmosphere
Löslichkeit	≤15mg/ml in DMSO;15mg/ml in dimethyl formamide
Aggregatzustand	solution in ethanol.
pka	8.84±0.40(Predicted)
Farbe	Light yellow to yellow
Stabilität	Hygroscopic, Light Sensitive
CAS Datenbank	2743-90-0

Sicherheit

R-Sätze:	25-36
S-Sätze:	24/25
RIDADR	2810
HazardClass	IRRITANT
HS Code	29399990

Gefahreninformationscode (GHS)

(R,S)-ANATABINE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
(R,S)-Anatabine is a minor alkaloid produced in plants of the Solanaceae family, including tobacco. The detection of (R,S)-anatabine in urine is used as an indicator of tobacco use, particularly when nicotine-containing products (gum, patches, inhalers, and medications) are also being used. (R,S)-Anatabine increases nicotine self-administration and locomotor activity in rats. Of note, (R,S)-anatabine diminishes amyloid-β production in vitro and in vivo. (R,S)-Anatabine reduces (600 μg/ml) the transcription and protein levels of β-secretase, lowering the amount of Aβ (1-40) and Aβ (1-42) in a dose dependent manner in SHSY-5Y cells. (R,S)-Anatabine also dose dependently inhibits NF-κB activation.
Chemische Eigenschaften
Light Yellow Oil
Verwenden
A nicotine (N412420) metabolite.
Verwenden
A nicotine metabolite
Verwenden
(R,S)-Anatabine is a metabolite of Nicotine (N412420).
in vitro
anatabine dose-dependently lowered aβ1-40 and aβ1-42 levels and reduced sappβ production without any effects on sappα levels. anatabine lowered aβ production by mainly impacting the β-cleavage of app. anatabine lowered nfκb activation. anatabine inhibited bace-1 transcription and reduced bace-1 protein levels in human neuronal like shsy-5y cells. (r,s)-anatabine also dose dependently inhibits nf-κb activation [1].
in vivo
in a transgenic mouse model of alzheimer's disease, acute treatment with anatabine for 4 days significantly lowered brain soluble aβ1-40 and aβ1-42 levels [1].
Einzelnachweise
[1] paris d, beaulieu-abdelahad d, bachmeier c, et al. anatabine lowers alzheimer's aβ production in vitro and in vivo[j]. european journal of pharmacology, 2011, 670(2): 384-391.

(R,S)-ANATABINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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