Fleroxacin

Bezeichnung:Fleroxacin

CAS-Nr79660-72-3

Englisch Name:Fleroxacin

CBNumberCB1331989

SummenformelC17H18F3N3O3

Molgewicht369.34

MOL-Datei79660-72-3.mol

Fleroxacin physikalisch-chemischer Eigenschaften

Schmelzpunkt	264-266°C
Siedepunkt	535.3±50.0 °C(Predicted)
Dichte	1.409±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	0.1 M NaOH: soluble10mg/mL
Aggregatzustand	solid
pka	-0.54±0.20(Predicted)
Farbe	white to off-white
Merck	14,4099
CAS Datenbank	79660-72-3(CAS DataBase Reference)

Sicherheit

WGK Germany	2
RTECS-Nr.	VB1999050
HS Code	29335990

Gefahreninformationscode (GHS)

Fleroxacin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Fleroxacin is a new, once daily trifluoroquinolone antibacterial structurally related to norfloxacin. Available in both oral and IV formulations, it is reportedly useful in the treatment of gonorrhea, bacterial enteritis, chronic bronchitis and urinary tract infections. Fleroxacin has a longer serum half-life (9-12 hours) than other drugs of this class, such as ciprofloxacin, enoxacin and norfloxacin.
Chemische Eigenschaften
White Needle-Like Crystals
Originator
Kyorin (Japan)
Verwenden
An antibacterial.
Verwenden
antibiotic
Definition
ChEBI: A fluoroquinolone antibiotic that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6, 7 and 8 by 2-fluoroethyl, carboxy, fluoro, 4-methylpiperazin-1-yl and fluoro groups, respectively. It is active against many Gram-positive and Gram-n gative bacteria.
Manufacturing Process
6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4- oxoquinoline-3-carboxylic acid hydrochloride:
A mixed solution of 1-methylpiperazine (0.34 g) and pyridine (3 ml) was added to 6,7,8-trifluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxoquinoline-3- carboxylic acid (0.12 g) and heated to reflux for 6 hours. After the solvent evaporated and cooled, the residue was adjusted to pH 1 with aqueous hydrochloric acid. The cooled mixture was filtered off and the solid recrystallized from water to give 6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7- (4-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrochloride (0.08 g), melting point 269-271°C (decomp.).
Trademarks
Quinodis
Therapeutic Function
Antibacterial

Fleroxacin Upstream-Materialien And Downstream Produkte

Fleroxacin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

79660-72-3, Fleroxacin Verwandte Suche:

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