MK2-IN-1 (hydrochloride)

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

MK2-IN-1 (hydrochloride) Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  mk2 inhibitor iv is a highly selective and non-atp competitive mk2 inhibitor with ic50 value of 0.11 μm [1].map kinase-activated protein kinase 2 (mapkapk2 or mk2) is a member of the ser/thr protein kinase family and regulated through direct phosphorylation by p38 map kinase. activation of the p38/mk2 pathway involved in promoting pro-inflammatory cytokine production and related inflammatory diseases [1].mk2 inhibitor iv is a highly selective and non-atp competitive mk2 inhibitor. in a broad panel of 150 protein kinases, mk2 inhibitor iv only significantly inhibited ck1γ3 at greater than 50%. mk2 inhibitor iv also demonstrated no inhibition against a panel of cytochrome p450 (cyp) enzymes up to 30 μm. in the human thp1 acute monocytic leukemia cell line, mk2 inhibitor iv inhibited pro-inflammatory cytokine secretion. mk2 inhibitor iv also dose-dependently inhibited lps-stimulated tnfα and il6 secretion with ic50 values of 4.4 μm and 5.2 μm, respectively. in the sw1353 chondrosarcoma cell line and human primary chondrocyte cultures, mk2 inhibitor iv dose dependently inhibited il1β-stimulated matrixmetalloprotease (mmp)13 secretion with ic50 values of 5.7 μm and 2.2 μm, respectively.

• Einzelnachweise

  [1]. huang x, shipps gw jr, cheng cc, et al. discovery and hit-to-lead optimization of non-atp competitive mk2 (mapkapk2) inhibitors. acs med chem lett. 2011 jun 24;2(8):632-7.

MK2-IN-1 (hydrochloride) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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