MLS-0315848 hydrochloride

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H318：Verursacht schwere Augenschäden.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

MLS-0315848 hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  1-(3,4-Dihydroxyphenyl)-2-(3-ethyl-1H-pyrazol-1-yl)ethanone Hydrochloride is a biochemical inhibitor of placental alkaline phosphatase (PLAP) and is used to elucidate the key biological functions and natural substrates of human PLAP.

• Biologische Aktivität

  ml-095 (hydrochloride) is a specific plap inhibitor [1].alkaline phosphatases are hydrolase enzymes responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. there are three isozymes of alkaline phosphatases: placental alkaline phosphatase (plap), intestinal alkaline phosphatase (iap), and tissue non-specific alkaline phosphatase (tnap). placental alkaline phosphatase (plap) is highly expressed in primate placental tissue and the biological function is still unknown. however, plap-like enzymes are detected in serum of patients with primary testicular tumors, in particular seminoma and other cancers [1].ml-095 (cid-25067483) is a biochemical inhibitor of plap and will be useful to elucidate the key biological functions and natural substrates of human plap. ml095 is a specific plap inhibitor and inhibited plap, tnap and iap with ic50 values of 2.1, >100 and 53 μm, respectively. ml095 exhibited greater than 25-fold selectivity over tissue non-specific alkaline phosphatase (tnap) and intestinal alkaline phosphatase (iap) [1].

• Einzelnachweise

  [1]. lanier m, cashman j, sergienko e, et al. placental alkaline phosphatase (plap) luminescent hts assay - probe 2.

MLS-0315848 hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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