SB242235

SB242235 Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  SB-242235 is a potent and selective p38 MAP kinase inhibitor with IC50 of 1.0 μM in human chondrocytes.

• in vitro

  SB 242235 (0-10 μM) dose-dependently inhibits the activation of MAPKAP K2 with an IC ₅₀ of 1.0 μM in human chondrocytes stimulated with IL-1β.
  SB 242235 inhibits intracellular p38 activity, MAPKAP K2 was then isolated from these cells and assayed using HSP27 as a substrate.
  

  Western Blot Analysis

  < td class="col2"> 15 minutes

  Cell Line:	Human chondrocytes
  Concentration:	0 μM, 0.01 μM, 0.1 μM, 1 μM, 10 μM
  Incubation Time:
  Result:	Dose-dependently inhibited the activation of MAPKAP K2 with an IC 50 of 1.0 μM.

• target

  IC50: 1.0 μM (p38 MAPK, primary human chondrocytes)

SB242235 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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