MPEG5-NHS

MPEG5-NHS Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  m-PEG6-NHS ester is a PEG linker containing an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The hydrophilic PEG spacer increases solubility in aqueous media.

• Biologische Aktivität

  MPEG5-NHS is a non-cleavable 6-unit PEG-containing ADC linker for the synthesis of antibody drug conjugates (ADCs). It is a PROTAC linker belonging to the PEG/Alkyl/ether class, which can be used to synthesize PROTAC molecules.

• in vitro

  ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
  PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

• target

  PEGs

  Alkyl/ether

  Non-cleavable

MPEG5-NHS Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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