Ristocetin A sulfate Struktur

Ristocetin A sulfate

Bezeichnung:Ristocetin A sulfate

CAS-Nr11140-99-1

Englisch Name:Ristocetin A sulfate

CBNumberCB1251133

SummenformelC95H112N8O48S

Molgewicht2166

MOL-Datei11140-99-1.mol

Ristocetin A sulfate physikalisch-chemischer Eigenschaften

Schmelzpunkt	>200°C (dec.)
storage temp.	2-8°C
Löslichkeit	DMSO (Slightly), Water (Slightly)
Aggregatzustand	Light tan solid.
Farbe	White to Pale Beige
Stabilität	Hygroscopic

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/38
S-Sätze:	22-24/25-37/39-26
RIDADR	3249
WGK Germany	3
RTECS-Nr.	VJ8650000
F	8-10-23
HazardClass	6.1(b)
PackingGroup	III
Toxizität	mouse,LD50,intravenous,660mg/kg (660mg/kg),BEHAVIORAL: TREMORLUNGS, THORAX, OR RESPIRATION: OTHER CHANGESBEHAVIORAL: EXCITEMENT,Antibiotiki i Meditsinskaya Biotekhnologiya. Antibiotics and Medical Biotechnology. Vol. 32, Pg. 910, 1987.

Gefahreninformationscode (GHS)

Ristocetin A sulfate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/38:Reizt die Augen und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Verwenden
Ristomycin Monosulfate is used in biological studies for ligand discovery of fluorescent HIV-1 Dimerization Initation Site.
Verwenden
Ristocetin A sulfate is a potent antibacterial glycopeptide antibiotic that was withdrawn from clinical use following a high incidence of thrombocytopenia. Further investigation found that ristocetin A induced platelet aggregation by binding to a factor absent in people suffering from von Willebrand's disease, leading to the use of ristocetin A as an important diagnostic aid.
Allgemeine Beschreibung
Ristomycin/ristocetin is a type III glycopeptide. It is a highly glycosylated glycopeptide, previously found in?Amycolatopsis lurida.
Biologische Aktivität
ristocetin a, a glycopeptide related to vancomycin, is an antibiotic produced by the microorganism nocardia lurida[1].ristocetin a is currently in clinical use to treat bacterial infections [1]. ristocetin a is an antibiotic which can be used to treat staphylococcal infections. the side effects of ristocetin a include thrombocytopenia and platelet agglutination. ristocetin a has been used in two assays: the ristocetin cofactor assay and the ristocetin-induced platelet aggregation assay. these two assays could be used to diagnosis the von willebrand disease and other bleeding disorders [2, 3]. the structural features of ristocetin a are similar to vancomycin.
Biochem/physiol Actions
Ristocetin activates platelets. Ristocetin-induced platelet agglutination (RIPA) is decreased in patients undergoing chronic hemodialysis. Together with increased plasma glycocalicin levels (a product of enzymatic cleavage of GPIb), RIPA may contribute to diminished platelet adhesion to vascular subendothelium and increased bleeding associated with uremia. Addition of ristocetin and vWf caused specific agglutination of rGPIbα-liposomes suporting the potential use of rGPIbα-liposomes to enhance platelet function in vivo and support hemostasis in thrombocytopenic individuals.
Einzelnachweise
[1] pearson a j, heo j n. approaches to the fully functionalized def ring system of ristocetin a via highly selective ruthenium-promoted snar reaction[j]. organic letters, 2000, 2(19): 2987-2990.hawks g h. antibiotic therapy of staphylococcal infections[j]. canadian medical association journal, 1965, 93(16): 848.
[3] castaman, g. ,hillarp, a. and goodeve, a. laboratory aspects of von willebrand disease: test repertoire and options for activity assays and genetic analysis. haemophilia 20(suppl 4), 65-70 (2014).

Ristocetin A sulfate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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