Casein Kinase II Inhibitor III Struktur

Casein Kinase II Inhibitor III

Bezeichnung:Casein Kinase II Inhibitor III

CAS-Nr934358-00-6

Englisch Name:Casein Kinase II Inhibitor III

CBNumberCB12501559

SummenformelC9H4Br4O2

Molgewicht463.74

MOL-Datei934358-00-6.mol

Casein Kinase II Inhibitor III physikalisch-chemischer Eigenschaften

Schmelzpunkt	189.2-191.2 °C
Siedepunkt	490.8±45.0 °C(Predicted)
Dichte	2.443±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	DMSO: soluble20mg/mL, clear
pka	3.83±0.16(Predicted)
Aggregatzustand	powder
Farbe	white to beige

Sicherheit

WGK Germany

Gefahreninformationscode (GHS)

Casein Kinase II Inhibitor III Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
Casein Kinase II Inhibitor III is a casein kinase 2 inhibitor. A protein kinase inhibitors used to elucidate cellular signaling pathways.
Biologische Aktivität
tetrabromocinnamic acid (tbca) is a new class of specific protein kinase ck2 inhibitors [1].protein kinases have been involved in catalyzing the phosphorylation of serine, threonine and tyrosine residues in protein substrates that play dominant roles in controlling nearly all cellular functions. the ser/thr-specific protein kinase ck2 has been implicated in signal transduction, gene expression, dna repair, rna and protein synthesis. ck2 is invariably elevated in a wide spectrum of tumours [1].
in vitro
tbca was a selective, cell-permeable inhibitor of ck2 with an ic50 of 0.11 μm. the ki value was 77 nm. tbca showed minimal effect on a panel of 28 other kinases. tbca induced cell death in jurkat adult t cell leukemia cells with an dc50 of 7.7 μm [1]. tbca dose-dependently inhibited platelet aggregation and secretion induced by various agonists including 2-mesadp, aypgkf, sfllrn, and crp [2]. tbca also significantly inhibited agonist-induced thromboxane a2 (txa2) generation and erk phosphorylation. tbca significantly inhibited platelet spreading on immobilized fibrinogen surface and clot retraction mediated by integrin αiibβ3 signaling [2].
Lager
Store at +4°C
Einzelnachweise
[1] pagano m a, poletto g, di maira g, et al. tetrabromocinnamic acid (tbca) and related compounds represent a new class of specific protein kinase ck2 inhibitors[j]. chembiochem, 2007, 8(1): 129-139.
[2] ryu s y, kim s. evaluation of ck2 inhibitor (e)-3-(2, 3, 4, 5-tetrabromophenyl) acrylic acid (tbca) in regulation of platelet function[j]. european journal of pharmacology, 2013, 720(1): 391-400.

Casein Kinase II Inhibitor III Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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