LY 294002 HYDROCHLORIDE

Bezeichnung:LY 294002 HYDROCHLORIDE

Englisch Name:LY 294002 HYDROCHLORIDE

CBNumberCB1242450

SummenformelC19H17NO3

Molgewicht307.34

LY 294002 HYDROCHLORIDE physikalisch-chemischer Eigenschaften

Schmelzpunkt	183-185℃
Siedepunkt	494.6±45.0 °C(Predicted)
Dichte	1.266
storage temp.	Sealed in dry,Store in freezer, under -20°C
Löslichkeit	DMSO: >5 mg/mL
Aggregatzustand	solid
pka	0.55±0.20(Predicted)
Farbe	white to off-white
Wasserlöslichkeit	Soluble in DMSO at 5mg/ml. Insoluble in water
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
InChIKey	CZQHHVNHHHRRDU-UHFFFAOYSA-N
CAS Datenbank	154447-36-6

Sicherheit

Gefahreninformationscode (GHS)

Beschreibung
LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC₅₀ of 1.4 μM.
Verwenden
LY 294002 Hydrochloride is a highly selective inhibitor of Phosphatidylinositol 3-kinase (PI3K). It is a salt analogue of LY 294002 (L486590).
Verwenden
LY 294002 is a Phosphatidylinositol 3-kinase (PI3K) inhibitor which has shown to block the formation of tumor tissues in bone marrow cavity an abolish multiple myeloma (MM) induced osteoclast formation and osteolysis in SCID mice.
Verwenden
LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC50 of 1.4 μM.
Verwenden
A potent blocker of PI 3-kinase/Akt signaling.
Definition
ChEBI: A chromone substituted with a phenyl group at position 8 and a morpholine group at position 2.
Biologische Aktivität
A highly selective inhibitor of phosphatidylinositol 3-kinase (IC 50 values are 0.31, 0.73, 1.06 and 6.60 μ M for PI3K β , PI3K α , PI3K δ and PI3K γ respectively). Inhibits proliferation and induces apoptosis in human colon cancer cells in vitro and in vivo .
target
p110α
Einzelnachweise
1) Vlahos et al. (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY 294002); J. Biol. Chem., 269 5241