Salsalat

Bezeichnung:Salsalat

CAS-Nr552-94-3

Englisch Name:Sasapyrine

CBNumberCB1240724

SummenformelC14H10O5

Molgewicht258.23

MOL-Datei552-94-3.mol

Synonyma

Salsalat

Salsalat physikalisch-chemischer Eigenschaften

Schmelzpunkt	139-151 °C
Siedepunkt	361.48°C (rough estimate)
Dichte	1.3326 (rough estimate)
Brechungsindex	1.4825 (estimate)
storage temp.	2-8°C
Löslichkeit	DMSO: ≥15mg/mL
pka	pKa 3.5 (Uncertain);9.8 (Uncertain)
Aggregatzustand	Crystalline Powder
Farbe	white to tan
Wasserlöslichkeit	HYDROLYSIS
Sensitive	Moisture Sensitive
Merck	14,8339
CAS Datenbank	552-94-3
NIST chemische Informationen	2-Carboxyphenyl salicylate(552-94-3)
EPA chemische Informationen	Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester (552-94-3)

Sicherheit

Kennzeichnung gefährlicher	Xi,N,Xn
R-Sätze:	36/37/38-50-22
S-Sätze:	37/39-26-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	3
RTECS-Nr.	DH2080000
TSCA	Yes
HS Code	29182300

Gefahreninformationscode (GHS)

Sasapyrine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Salsalate, or salicylsalicylic acid, (pKa 3.5 [COOH], 9.8 [AR-OH]) is a dimer of salicylic acid. It is insoluble in gastric juice but is soluble in the small intestine, where it is partially hydrolyzed to two molecules of salicylic acid and absorbed. On a molar basis, it produces 15% less salicylic acid than aspirin. It does not cause GI blood loss and can be given to aspirin-sensitive patients. Salsalate is available as capsules and tablets.
Chemische Eigenschaften
white crystalline powder
Verwenden
Salicylsalicylic acid is used in organic synthesis and functions as a plant hormone, as a key ingredient in topical anti-acne products.
Verwenden
Nonacetylated (e.g., sodium salicylate) and acetylated (aspirin) forms of salicylate are widely used to target inflammation in the treatment of insulin resistance, type 2 diabetes, or rheumatic pain. Sasapyrine is a dimeric prodrug comprising two esterified salicylate moieties. It is advantageous over sodium salicylate because it is insoluble at the acid pH of the stomach and passes suspended but undissolved into the small intestine, sparing the gastric mucosa direct contact.
Verwenden
Nonacetylated aspirin analog. Analgesic, anti-inflammatory.
Definition
ChEBI: A dimeric benzoate ester obtained by intermolecular condensation between the carboxy of one molecule of salicylic acid with the phenol group of a second. It is a prodrug for salycylic acid that is used for treatment of rheumatoid arthritis and osteoarthrit s and also shows activity against type II diabetes.
Trademarks
Disalcid (3M Pharmaceuticals).
Allgemeine Beschreibung
Salsalate, salicylsalicylic acid (Amigesic, Disalcid,Salflex), is the ester formed between two salicylic acidmolecules. It is rapidly hydrolyzed to salicylic acid followingits absorption. It reportedly causes less gastric irritationthan aspirin, because it is relatively insoluble inthe stomach and is not absorbed until it reaches the smallintestine.
Biochem/physiol Actions
Salsalate is a nonsteroidal anti-inflammatory drug (NSAID), a nonacetylated salicylate with no more problems of gastrointestinal bleeding than placebo. It inhibits synthesis and release of prostaglandins through the inactivation of cyclooxygenase-1 (COX-1) and COX-2. Salsalate is currently being investigated as a treatment for Type 2 diabetes with possible use to prevent the disease in people at risk. It reduces blood glucose concentrations in patients with type 2 diabetes, as well as in insulin-resistant patients without diabetes.

Salsalat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

552-94-3, Sasapyrine Verwandte Suche:

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