Glutathione Ethyl Ester Struktur

Glutathione Ethyl Ester

Bezeichnung:Glutathione Ethyl Ester

CAS-Nr92614-59-0

Englisch Name:Glutathione Ethyl Ester

CBNumberCB12130580

SummenformelC12H21N3O6S

Molgewicht335.38

MOL-Datei92614-59-0.mol

Glutathione Ethyl Ester physikalisch-chemischer Eigenschaften

Siedepunkt	644.3±55.0 °C(Predicted)
Dichte	1.314±0.06 g/cm3(Predicted)
storage temp.	-20°C
Löslichkeit	PBS (pH 7.2): 10 mg/ml; Water: 20 mg/ml
Aggregatzustand	A crystalline solid
pka	2.21±0.10(Predicted)

Sicherheit

WGK Germany

Glutathione Ethyl Ester Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Glutathione (GSH) serves as a nucleophilic co-substrate to glutathione transferase in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of hydroperoxides. GSH ethyl ester is a cell-permeable derivative of GSH that undergoes hydrolysis by intracellular esterases to release GSH. Effective transport of GSH ethyl ester has been used to protect cells against damage from radiation, oxidants, and various toxic compounds including heavy metals.
Verwenden
Glutathione (GSH) serves as a nucleophilic co-substrate to glutathione transferase in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of hydroperoxides. GSH ethyl ester is a cell permeable derivative of GSH that undergoes hydrolysis by intracellular esterases to release GSH. Effective transport of GSH ethyl ester has been used to protect cells against damage from radiation, oxidants, and various toxic compounds including heavy metals.
Verwenden
Glutathione reduced ethyl ester has been used:
- to increase intracellular glutathione levels in mouse fibroblast L929 cells
- as a medium supplement in Spodoptera frugiperda (Sf)9 cells
- to evaluate its effect on lipid peroxidation after spinal cord injury
Biochem/physiol Actions
Glutathione reduced ethyl ester (GSH-MEE) is a membrane/lipid permeable derivative of GSH that may be used to partially supplement the GSH supply within cells subjected to cysteine and/or GSH depletion. GSH-MEE is hydrolysed by intracellular esterases to release GSH, thereby increases the concentrations of intracellular GSH. It prevents the toxic effects of acetaminophen in animal cells. It protects human lymphoid cells and skin fibroblasts against the damage caused due to radiation.

Glutathione Ethyl Ester Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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