enniatin B1

Bezeichnung:enniatin B1

CAS-Nr19914-20-6

Englisch Name:enniatin B1

CBNumberCB12079102

SummenformelC34H59N3O9

Molgewicht653.85

MOL-Datei19914-20-6.mol

enniatin B1 physikalisch-chemischer Eigenschaften

Schmelzpunkt	178.5 °C
Siedepunkt	833.8±65.0 °C(Predicted)
Dichte	1.031±0.06 g/cm3(Predicted)
storage temp.	-20°C
Löslichkeit	DMSO: soluble10mg/mL
Aggregatzustand	White to off-white crystalline solid.
pka	-1.45±0.70(Predicted)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	23/24/25
S-Sätze:	45
RIDADR	2811
WGK Germany	3
HazardClass	6.1(a)
PackingGroup	I
HS Code	2941900000

Gefahreninformationscode (GHS)

enniatin B1 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
Enniatins are a family of depsipeptide ionophores, produced several Fusarium species. More recently, the effects of the enniatins on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumour action have received more focus. Enniatin B1 is one of four major analogues of the enniatin complex and has not previously been available for investigation.
Verwenden
Enniatins are a family of depsipeptide ionophores produced by several Fusarium species. Recently, the effects of the enniatins on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus. Enniatin B1 is one of four major analogues of the enniatin complex.
Verwenden
Enniatins are cyclohexadepsipeptides commonly isolated from fungi and are known to have antibiotic properties. Many act as ionophores, forming pores in cellular membranes to allow selective ion transport. Enniatin B1 is one of four major analogs of the enniatin complex . It has been shown to induce apoptosis in several cancer lines (EC50s ≤ 10 μM) and to decrease the activation of the cell proliferation kinase, ERK (p44/p42). Enniatin B1 also inhibits the multi-drug resistance transporter Pdr5p from S. cerevisiae and has been used to examine drug resistance mechanisms.
Biochem/physiol Actions
Enniatins are a group of cyclohexadepsipeptide mycotoxins produced by Gnomonia errabuda and several Fusaria species, with phytotoxic, antibiotic, and insecticidal activities. Enniatins function as ionophors by their incorporation into the cellular membrane to form dimeric structures that transport monovalent ions across the membrane (especially the mitochondrial membranes) affecting oxidative phosphorylation uncoupling. It has been demonstrated that enniatins have a cytotoxic effect on human cancer cells. Furthermore, incubation of H4IIE hepatoma cells with enniatins strongly diminished phosphorylation of the ERK (p44/p42). Enniatins B and B1 inhibit the multi-drug resistance transporter Pdr5p from Saccharomyces cerevisiae, indicating their beneficial potential in cases of drug resistant patients.

enniatin B1 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

19914-20-6, enniatin B1 Verwandte Suche:

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