Isobutyrophenon

Bezeichnung:Isobutyrophenon

CAS-Nr611-70-1

Englisch Name:Isobutyrophenone

CBNumberCB1180914

SummenformelC10H12O

Molgewicht148.2

MOL-Datei611-70-1.mol

Synonyma

Isobutyrophenon

Isobutyrophenon physikalisch-chemischer Eigenschaften

Schmelzpunkt	1 °C
Siedepunkt	217 °C (lit.)
Dichte	0.988 g/mL at 25 °C (lit.)
Dampfdruck	1 mm Hg ( 50 °C)
Brechungsindex	n20/D 1.517(lit.)
Flammpunkt	184 °F
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	Chloroform (Sparingly), Methanol (Slightly)
Aggregatzustand	Oil
Farbe	Colourless
Wasserlöslichkeit	immiscible
BRN	774499
LogP	2.73
CAS Datenbank	611-70-1(CAS DataBase Reference)
NIST chemische Informationen	Isopropyl phenyl ketone(611-70-1)
EPA chemische Informationen	1-Propanone, 2-methyl-1-phenyl- (611-70-1)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
TSCA	Yes
HS Code	29143900

Gefahreninformationscode (GHS)

Isobutyrophenone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
clear colorless to very slightly yellow liquid
Verwenden
Isobutyrophenone is used as an internal standard in the determination of hydroxyzine hydrochloride and benzyl alcohol in injection solutions. It is also used in the preparation of alpha-hydroxyisobutyrophenone. Isobutyrophenone is employed as photosensitizer intermediate. It can react with bromoacetic acid ethyl ester to get 3-hydroxy-4-methyl-3-phenyl-valeric acid ethyl ester.
synthetische
Isobutyrophenone synthesis: Benzene underwent a Friedel–Crafts acylation with isobutyryl chloride to synthesize isobutyrophenone. The reaction was performed using excess benzene as a replacement for a typical solvent and heat to reflux (88 °C) for a period of 3 hours. Any unreacted benzene was recovered after the reaction during the distillation process. A 66 % yield of isobutyrophenone was obtained from the solar synthesis, compared to a 44 % yield from an in-lab, electrical heating analysis.
Synthesis Reference(s)
Journal of the American Chemical Society, 71, p. 1061, 1949 DOI: 10.1021/ja01171a084
The Journal of Organic Chemistry, 32, p. 404, 1967 DOI: 10.1021/jo01288a032
Tetrahedron Letters, 14, p. 2491, 1973
Flammability and Explosibility
Non flammable

Isobutyrophenone Upstream-Materialien And Downstream Produkte

Isobutyrophenon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

611-70-1, Isobutyrophenone Verwandte Suche:

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