N-HYDROXYPROPIONAMIDINE

Bezeichnung:N-HYDROXYPROPIONAMIDINE

CAS-Nr29335-36-2

Englisch Name:N-HYDROXYPROPIONAMIDINE

CBNumberCB1176256

SummenformelC3H8N2O

Molgewicht88.11

MOL-Datei29335-36-2.mol

N-HYDROXYPROPIONAMIDINE physikalisch-chemischer Eigenschaften

Siedepunkt	132.8±23.0 °C(Predicted)
Dichte	1.12±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	7.48±0.69(Predicted)
Aussehen	Colorless to off-white Viscous Liquid
Wasserlöslichkeit	Slightly soluble in water.
Sensitive	Hygroscopic
CAS Datenbank	29335-36-2

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	36/37/38-25
S-Sätze:	26-36/37/39-45
RIDADR	UN3267
HazardClass	8
PackingGroup	III
HS Code	2925290090

Gefahreninformationscode (GHS)

N-HYDROXYPROPIONAMIDINE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Verwenden
Propionamidoxime is used as pharmaceutical intermediate.
Synthese

107-12-0

29335-36-2

The general procedure for the synthesis of N-hydroxypropionic acid amidine from propionitrile was as follows: hydroxylamine hydrochloride (18.9 g, 272.7 mmol) and anhydrous potassium carbonate (37.6 g, 272.7 mmol) were suspended in a mixed solvent of ethanol/water (200 mL/50 mL), and stirred for 1 h at room temperature. Subsequently, propionitrile (10.0 g, 181.8 mmol) was added to the reaction system. The reaction mixture was heated to reflux and stirred continuously for 20 h. The reaction process was monitored by thin layer chromatography (unfolding agent: dichloromethane/methanol, 50/1 volume ratio). Upon completion of the reaction, the inorganic salts were removed by filtration and the filtrate was concentrated under reduced pressure to afford N-hydroxypropionic acid amidine (13.5 g, 81% yield) as a light yellow solid.
Einzelnachweise
[1] Patent: CN104513235, 2017, B. Location in patent: Paragraph 1308; 1309
[2] Chemische Berichte, 1884, vol. 17, p. 2753
[3] Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1957, vol. 245, p. 419,420
[4] Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1966, vol. 262, p. 592 - 595
[5] Monatshefte fuer Chemie, 1982, vol. 113, p. 781 - 792

N-HYDROXYPROPIONAMIDINE Upstream-Materialien And Downstream Produkte

N-HYDROXYPROPIONAMIDINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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