DIMETHYL DL-GLUTAMATE HYDROCHLORIDE

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P271：Nur im Freien oder in gut belüfteten Räumen verwenden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P302+P352：BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.

  P304+P340：BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

  P312：Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P321：Besondere Behandlung

  P332+P313：Bei Hautreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

  P337+P313：Bei anhaltender Augenreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

  P403+P233：An einem gut belüfteten Ort aufbewahren. Behälter dicht verschlossen halten.

  P405：Unter Verschluss aufbewahren.

  P501：Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

DIMETHYL DL-GLUTAMATE HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  While extracellular glutamic acid is an excitatory neurotransmitter, intracellular glutamic acid is an amino acid that serves numerous metabolic roles. Dimethyl DL-glutamate is a cell-permeant glutamic acid derivative that enhances insulin release in response to glucose in isolated islets and in animal models of diabetes. It also potentiates the insulinotropic potential of glyburide and glucagon-like peptide 1. Dimethyl DL-glutamate is used as a cell-permeable form of glutamate in studies of glutamate action in β-cells. However, it can be cytotoxic to myeloid cells and act as an antagonist of glutamate-mediated neurosignaling.

• Verwenden

  While extracellular glutamic acid is an excitatory neurotransmitter, intracellular glutamic acid is an amino acid that serves numerous metabolic roles. Dimethyl DL-glutamate Hydrochloride is a cell-permeant glutamic acid derivative that enhances insulin release in response to glucose in isolated islets and in animal models of diabetes. It also potentiates the insulinotropic potential of glyburide and glucagon-like peptide 1. Dimethyl DL-glutamate Hydrochloride is used as a cell-permeable form of glutamate in studies of glutamate action in β-cells. However, it can be cytotoxic to myeloid cells and act as an antagonist of glutamate-mediated neurosignaling.

• in vitro

  dimethyl dl-glutamate at 3.0-10.0 mm could enhance insulin release evoked by 6.0-8.3 mm d-glucose, 1.0-10.0 mm l-leucine, or 5.0-10.0 mm 2-amino-bicyclo(2,2,1)heptane-2-carboxylic acid, resulting in a shift to the left of the sigmoidal relationship between insulin output and d-glucose concentration. moreover, dimethyl dl-glutamate unmasked the insulinotropic potential of glibenclamide in the absence of d-glucose. in islets exposed to l-leucine, the insulinotropic action of dimethyl dl-glutamate coincided with an early fall and later increase in 86rb outflow. in addition, the overall gain in o2 uptake represented the balance between dimethyl dl-glutamate oxidation and its sparing action on the catabolism of endogenous fatty acids and exogenous d-glucose [1].

• in vivo

  dimethyl dl-glutamate was intravenously administered as a primed constant infusion to adult rats that had been injected with streptozotocin during the neonatal period. results showed that dimethyl dl-glutamate augmented plasma insulin concentration and potentiated and/or prolonged the insulinotropic action of glp-1 injected intravenously at min 5 of the test [2].

• Einzelnachweise

  [1] sener, a. ,conget, i.,rasschaert, j., et al. insulinotropic action of glutamic acid dimethyl ester. american journal of physiology 267(4 pt 1), e573-e584 (1994).
  [2] cancelas, j. ,villaneuva-peacarrillo, m.l.,valverde, i., et al. potentiation and prolongation of the insulinotropic action of glucagon-like peptide 1 by methyl pyruvate or dimethyl ester of l-glutamic acid in a type 2 diabetes animal model. endocrine 16(2), 113-116 (2001).

DIMETHYL DL-GLUTAMATE HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(96)Suppliers

13515-99-6, DIMETHYL DL-GLUTAMATE HYDROCHLORIDE Verwandte Suche: