3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  O8 OGG1 Inhibitor is potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC50 = 0.2 μM in a gel based assay). Exhibits > 200-fold selectivity for OGG1 over other DNA glycosylases, NEIL1 and NTH1.

• Allgemeine Beschreibung

  Inhibition of 8-oxoguanine DNA glycosylase-1 (OGG1) can be used in monotherapy or in combination therapy to treat some types of cancer.

• Biochem/physiol Actions

  OGG1 Inhibitor O8 is a potent inhibitor of 8-Oxoguanine DNA Glycosylase-1 (OGG1), part of the DNA base excision repair (BER) pathway that is becoming a drug target for cancer therapy. OGG1 Inhibitor O8 has an IC50 value of 220 nM and >100-fold selectivity for OGG1 relative to several other DNA repair glycosylases. O8 acts through the inhibition of Schiff base formation during OGG1 catalysis. It does not prevent DNA binding of OGG1 to a 7,8-dihydro-8-oxoguanine (8-oxo-Gua)-containing substrate.

• Lager

  Store at +4°C

3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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