Deslorelin

Bezeichnung:Deslorelin

CAS-Nr57773-65-6

Englisch Name:Deslorelin

CBNumberCB1144228

SummenformelC64H83N17O12

Molgewicht1282.48

MOL-Datei57773-65-6.mol

Deslorelin physikalisch-chemischer Eigenschaften

Schmelzpunkt	>189oC
alpha	D24 -61° (c = 0.37 in 0.1M acetic acid)
Dichte	1.48±0.1 g/cm3(Predicted)
storage temp.	−20°C
Löslichkeit	Acetic acid (Slightly), DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	9.82±0.15(Predicted)
Farbe	White to Off-White
Sequenz	Pyr-His-Trp-Ser-Tyr-DTrp-Leu-Arg-Pro-NHEt
InChIKey	GJKXGJCSJWBJEZ-QCOVUDKBNA-N
CAS Datenbank	57773-65-6(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	60
S-Sätze:	53-22-36/37/39-45
WGK Germany	3
RTECS-Nr.	OK6755000
HS Code	3504009000

Gefahreninformationscode (GHS)

Deslorelin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R60:Kann die Fortpflanzungsfähigkeit beeinträchtigen.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Deslorelin is an injectable gonadotropin releasing hormone super-agonist also known as an LHRH agonist. It stops the production of sex hormones with potential antineoplastic activity. Deslorelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Continuous, prolonged administration of goserelin in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production.
Chemische Eigenschaften
White powder, tens of times more biologically active than natural LH-RH, is synthesized by solid-phase or liquid-phase synthesis method using the corresponding protected amino acid monomers as raw materials.
Verwenden
Induction of ovulation in estrous mares Reproduction control in dogs
Definition
ChEBI: Deslorelin is an oligopeptide.
Trademarks
Somagard [as acetate] (Roberts Pharmaceutical).
Allgemeine Beschreibung
Deslorelin (brand names: SucroMate, Suprelorin F, Suprelorin 12, Suprelorin-6) is a synthetic hormone used to induce ovulation and manage artificial insemination programs in horses, modulate reproduction in dogs, or manage adrenal disease in ferrets. In the U.S., deslorelin is only FDA approved for use in mares and ferrets, and 'off label' or 'extra-label' use is prohibited at this time.
Nebenwirkungen
The most common side effects include swelling, sensitivity, and redness or warmth at the injection site. Rarely reported side effects in dogs include prolonged estrus and uterine infections.
Veterinary Drugs and Treatments
Deslorelin is approved for inducing ovulation in estrual mares. There is also interest in developing dosages and dosage forms as a long-term, reversible contraceptive in a variety of animal species, as a treatment for prostatic disease in male dogs, and incontinence in ovariectomized dogs. At the time of writing, deslorelin in not available in the USA, but is marketed in Canada.
In humans, deslorelin has been investigated for treating children with precocious puberty, and in adults for prostate carcinoma, dysmenorrhea, fibroids, and endometriosis.
Einzelnachweise
[1] CLAIRE GROSSET. Contraceptive effect and potential side-effects of deslorelin acetate implants in rats (Rattus norvegicus): preliminary observations.[J]. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2012, 76 3: 209-214.
[2] STEFANO ROMAGNOLI. Chronic Use of Deslorelin in Dogs: Six Cases (2005-2022).[J]. Animals, 2023, 13 2. DOI:10.3390/ani13020265.
[3] K E OERTER. Adult height in precocious puberty after long-term treatment with deslorelin.[J]. Journal of Clinical Endocrinology & Metabolism, 1991, 73 6: 1235-1240. DOI:10.1210/jcem-73-6-1235.

Deslorelin Upstream-Materialien And Downstream Produkte

Deslorelin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

57773-65-6, Deslorelin Verwandte Suche:

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