3-HYDRAZINO-QUINOXALINE-2-THIOL

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H370：Schädigt die Organe.

• Sicherheit

  P260：Dampf/Aerosol/Nebel nicht einatmen.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P270：Bei Gebrauch nicht essen, trinken oder rauchen.

  P405：Unter Verschluss aufbewahren.

3-HYDRAZINO-QUINOXALINE-2-THIOL Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  HPi1 is a potent, selective and orally active antibacterial agent against Helicobacter pylori with IC50 of 0.24 μM and MIC of 0.08-0.16 μg/mL. It is inactive against other bacteria, including the enteric bacteria Lactobacillus casei, Lactobacillus reuteri and Bifidobacterium longum.

• in vitro

  The MIC against H. pylori isolates ranged from 0.002-0.032 μg/mL (0.01-0.17 μM) in the agar dilution assay. HPi1 is effective against the clarithromycin-resistant strains ARHp172 (MIC of 0.004–0.016 μg/mL) and ARHp246 (MIC of 0.008–0.032 μg/mL).
  HPi1 has some activity against the Bacteroides species , but at concentrations at least 18- fold higher than the H. pylori MIC. More potent activity is detected for Campylobacter jejuni with an MIC of 0.3 μg/mL.
  HPi1 has good physicochemical and pharmacological properties, including determining the aqueous solubility (19 μg/mL), human plasma protein binding (93% bound), stability with human liver microsomes (T _1/2 of 1.3 hours) and the ability to passively permeate membranes.

• target

  IC50: 0.24 μM ( Helicobacter pylori )
  MIC: 0.08-0.16 μg/mL ( Helicobacter pylori )

3-HYDRAZINO-QUINOXALINE-2-THIOL Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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