Fudosteine

Bezeichnung:Fudosteine

CAS-Nr13189-98-5

Englisch Name:Fudosteine

CBNumberCB1128341

SummenformelC6H13NO3S

Molgewicht179.24

MOL-Datei13189-98-5.mol

Fudosteine physikalisch-chemischer Eigenschaften

Schmelzpunkt	200-202°C (dec.)
Siedepunkt	354.5±42.0 °C(Predicted)
Dichte	1.301±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	Water (Slightly)
Aggregatzustand	Solid
pka	2.09±0.10(Predicted)
Farbe	White to Light Brown
CAS Datenbank	13189-98-5(CAS DataBase Reference)

Gefahreninformationscode (GHS)

Fudosteine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Fudostein was launched in Japan as a new mucoactive agent for the treatment of bronchitis and respiratory congestion. This cysteine derivative was obtained from L-cysteine by condensation with either allylic alcohol in the presence of potassium persulfate or the corresponding bromoalcohol in the presence of a base. Fudostein was shown to significantly reduce mucus glycoprotein hypersecretion and inhibit infiltration of airway mucosa by lymphocytes and inflammatory cells in bronchitic rats. When given to bronchitic rabbits, an oral dose of 500 mg/kg daily potently decreased the fucose/ N-acetylneuraminic acid in sputa, so exhibiting mucoregulatory properties. In another study with SO₂-exposed rabbits, fudostein suppressed blood flow of tracheal microvasculature increased by SO₂, partly due to scavenging of superoxide anion.
Beschreibung
Fudosteine is a cysteine derivative that interferes with the increase in goblet cell number, expression of the mucin MUC5AC, and subsequent mucin secretion, in airways agonized with tobacco smoke, isoproterenol, lipopolysaccharide, TNF-α, or oxidants. Fudosteine, which is a thiol compound with antioxidant properties, limits NF-κB signaling and reduces inflammatory gene expression. It has greater bioavailability than N-acetyl-cysteine and increases cysteine levels in cells.
Chemische Eigenschaften
Off-White Powder
Originator
SS Pharmaceutical/Mitsubishi Pharma (Japan)
Verwenden
Fudosteine is a cysteine derivative that interferes with the increase in goblet cell number, expression of the mucin MUC5AC, and subsequent mucin secretion, in airways agonized with tobacco smoke, isoproterenol, lipopolysaccharide, TNF-α, or oxidants. Fudosteine, which is a thiol compound with antioxidant properties, limits NF-κB signaling and reduces inflammatory gene expression. It has greater bioavailability than N-acetyl-cysteine and increases cysteine levels in cells.
Verwenden
A demonstrated antiinflammatory
Verwenden
Fudosteine is a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor. MUC5AC mucin synthesis and the expression of the MUC5AC gene were increased by LPS in rats or TNF-α in NCI-H292 cells; these effects were inhibited by fudosteine treatment
Verwenden
An antiinflammatory expectorant used in the treatment of MUC5 mucin obstructive pulmonary disease.
Verwenden
An antiinflammatory expectorant MUC5 mucin obstructive pulmonary disease.
Definition
ChEBI: Fudosteine is an organic molecular entity.
Trademarks
Cleanal, Spelear (Mitsubishi Pharma)
Hazard
A reproductive hazard.
Synthese
Fudosteine is synthesized by condensation of L-cysteine with 3-bromopropyl alcohol in aqueous NaOH, or by condensation of L-cysteine with allyl alcohol by means of aqueous potassium persulfate.

Fudosteine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

13189-98-5, Fudosteine Verwandte Suche:

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