Dmophebumine

Dmophebumine Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Monzal ,Boenhringer Ingelheim

• Definition

  ChEBI: Vetrabutine is a member of benzenes and an organic amino compound.

• Manufacturing Process

  1.5 mole magnesium and 1 mole 3-phenylpropyl bromide were used for preparing of ester solution of Grignar reagent. 1 mole (3,4- dimethoxyphenyl)dimethylaminoacetonitrile in absolute ester was added to above reagent dropwise. Then the mixture was heated for 3 hours to reflux. On cooling it was poured into ice with 12% hydrochloric acid. The ester layer was separated. The water layer was alkalized with concentrate ammonia and ammonium chloride. The precipitated oil was dissolved in ester, dried over sodium sulfate and distilled in vacuum after removing of ester to give α-(3,4- dimethoxyphenyl)-N,N-dimethylbenzenebutanamine (vertabutine); BP: 166°- 168°C/0.1 mm Hg. Yield 85%. The free base may be turn into colorless hydrochloride by adding of equivalent of hydrochloric acid in ester; MP: 146°- 148°C.

• Therapeutic Function

  Uterine relaxant

Dmophebumine Upstream-Materialien And Downstream Produkte

Dmophebumine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(3)Suppliers

3735-45-3, Dmophebumine Verwandte Suche: