2-Brom-4'-methylacetophenon

Bezeichnung:2-Brom-4'-methylacetophenon

CAS-Nr619-41-0

Englisch Name:2-Bromo-4'-methylacetophenone

CBNumberCB1116041

SummenformelC9H9BrO

Molgewicht213.07

MOL-Datei619-41-0.mol

Synonyma

2-Brom-4'-methylacetophenon

2-Brom-4'-methylacetophenon physikalisch-chemischer Eigenschaften

Schmelzpunkt	45-49 °C(lit.)
Siedepunkt	238-239 °C(lit.)
Dichte	0.993 g/mL at 25 °C(lit.)
Brechungsindex	n20/D 1.528(lit.)
Flammpunkt	229 °F
storage temp.	2-8°C
Löslichkeit	Chloroform (Slightly), Ethyl Acetate
Aggregatzustand	Crystalline Powder or Needles
Farbe	White to light yellow
BRN	607041
Stabilität	Stable. Incompatible with strong oxidizing agents, strong bases.
InChI	InChI=1S/C9H9BrO/c1-7-2-4-8(5-3-7)9(11)6-10/h2-5H,6H2,1H3
InChIKey	KRVGXFREOJHJAX-UHFFFAOYSA-N
SMILES	C(=O)(C1=CC=C(C)C=C1)CBr
CAS Datenbank	619-41-0(CAS DataBase Reference)
NIST chemische Informationen	Ethanone, 2-bromo-1-(4-methylphenyl)-(619-41-0)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-27-37/39
RIDADR	UN 2811
WGK Germany	3
Hazard Note	Irritant
HazardClass	6.1
PackingGroup	III
HS Code	29147000
Speicherklasse	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

Gefahreninformationscode (GHS)

2-Bromo-4'-methylacetophenone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S27:Beschmutzte, getränkte Kleidung sofort ausziehen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
White to light yellow crystal powder
Verwenden
2-Bromo-4′-methylacetophenone was used in the general fluorous thiol quenching method. It was also used in the preparation of hydroxyquinolinone and N-derivatized carboxamides.
Allgemeine Beschreibung
2-Bromo-4′-methylacetophenone is an α-bromoketone.
Synthese

622-97-9

619-41-0

General procedure: 4-methylstyrene (1 mmol) was dissolved in a solvent mixture of acetone (3 mL) and water (0.1 mL) at room temperature. Subsequently, dibromo-p-toluenesulfonamide (TsNBr2, 2.2 mmol) was slowly added to this solution. After the reaction was complete, sodium thiosulfate (~200 mg) was added to quench the reaction and stirring was continued for 10 minutes. The reaction mixture was extracted with ethyl acetate and the organic phase was dried over anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under reduced pressure to remove the solvent. The crude product was purified by column chromatography on silica gel (230-400 mesh), the eluent being a mixed petroleum ether-ethyl acetate solvent, to give the final pure 2-bromo-4'-methylacetophenone.
Einzelnachweise
[1] Tetrahedron Letters, 2015, vol. 56, # 2, p. 356 - 358
[2] Organic and Biomolecular Chemistry, 2016, vol. 14, # 48, p. 11389 - 11395
[3] Green Chemistry, 2013, vol. 15, # 8, p. 2175 - 2179
[4] Synlett, 2010, # 15, p. 2335 - 2339
[5] Organic Letters, 2015, vol. 17, # 11, p. 2704 - 2707

2-Bromo-4'-methylacetophenone Upstream-Materialien And Downstream Produkte

2-Brom-4'-methylacetophenon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

619-41-0, 2-Bromo-4'-methylacetophenone Verwandte Suche:

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