D-BIOTIN P-NITROPHENYL ESTER Struktur

D-BIOTIN P-NITROPHENYL ESTER

Bezeichnung:D-BIOTIN P-NITROPHENYL ESTER

CAS-Nr33755-53-2

Englisch Name:D-BIOTIN P-NITROPHENYL ESTER

CBNumberCB1101472

SummenformelC16H19N3O5S

Molgewicht365.4

MOL-Datei33755-53-2.mol

D-BIOTIN P-NITROPHENYL ESTER physikalisch-chemischer Eigenschaften

Schmelzpunkt	163-165 °C(lit.)
Siedepunkt	642.9±50.0 °C(Predicted)
Dichte	1.326±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	methanol: soluble25mg/mL, clear, colorless to greenish-yellow
pka	13.89±0.40(Predicted)
Aggregatzustand	Solid
Farbe	White to Off-White
Optische Aktivität	[α]25/D +51°, c = 2 in DMF: AcOH (99:1)
BRN	5795805
InChIKey	YUDNXDTXQPYKCA-OWYJLGKBSA-N
CAS Datenbank	33755-53-2

Sicherheit

S-Sätze:	22-24/25
WGK Germany	3
F	10-21
HS Code	29349990

Gefahreninformationscode (GHS)

D-BIOTIN P-NITROPHENYL ESTER Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
White to off-white powder
Verwenden
For research use only. Not for use in diagnostic procedures.
Brain natriuretic peptide EIA Kit has been used to measure brain natriuretic peptide (BNP) secreted in human neonatal ventricular cardiomyocyte culture.
Verwenden
(+)-Biotin 4-nitrophenyl ester may be used in the preparation of biotin tagged ARC (adenosine-oligoarginine conjugate) derivative during cellular protein uptake studies. It may also be used to prepare biotinylated quinazoline derivatives, which shows inhibitory activities against VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinase. (+)-Biotin 4-nitrophenyl ester undergoes hydrolysis in the presence of Na[¹⁷O]H to form [¹⁷O₂]biotin, which can be used in solid-state ¹⁷O NMR spectroscopic experiments to analyze large protein-ligand complexes.
Allgemeine Beschreibung
The BNP Enzyme Immunoassay (EIA) Kit is an in vitro quantitative assay for detecting BNP peptide based on the principle of Competitive Enzyme Immunoassay.
Biochem/physiol Actions
Brain natriuretic peptide (BNP) expressed in mammalian brain and atrial natriuretic peptide (ANP) facilitates various physiological functions including regulation of blood pressure and cardiac remodeling. BNP acts as a potential biomarker of high left ventricular end-diastolic pressure in patients with symptomatic left ventricular (LV) dysfunction. Elevated expression of BNP is observed in acute myocardial infarction (AMI) patients. BNP is also implicated in several biological functions such as diuresis, natriureis, hypotensive action and inhibition of aldosterone secretion.
läuterung methode
The ester has been recrystallised by dissolving 2g in 95% EtOH (30mL), heated to dissolve, then cooled in an ice-water bath. The crystals are collected, washed with ice-cold 95% EtOH (5mL) and dried over P2O5. The RF on silica plates (CHCl3/MeOH 19:1) is 0.19 [Bodanszky & Fagan J Am Chem Soc 99 235 1977].

D-BIOTIN P-NITROPHENYL ESTER Upstream-Materialien And Downstream Produkte

D-BIOTIN P-NITROPHENYL ESTER Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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