Selamectin

Bezeichnung:Selamectin

CAS-Nr220119-17-5

Englisch Name:Selamectin

CBNumberCB0947411

SummenformelC43H63NO11

Molgewicht769.97

MOL-Datei220119-17-5.mol

Selamectin physikalisch-chemischer Eigenschaften

Schmelzpunkt	>180°C
Siedepunkt	917.0±65.0 °C(Predicted)
Dichte	1.35±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	Chloroform (Slightly), Dichloromethane (Slightly, Heated), DMSO (Slightly)
Aggregatzustand	Solid
pka	10.34±0.70(Predicted)
Farbe	White to Yellow
Stabilität	Hygroscopic
InChIKey	AFJYYKSVHJGXSN-KAJWKRCWSA-N
CAS Datenbank	220119-17-5

Sicherheit

WGK Germany	3
HS Code	2932206000

Gefahreninformationscode (GHS)

Selamectin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Selamectin is formulated as a spot-on for cats and dogs to control fleas (Ctenocephalides spp.) and flea-allergy dermatitis, to prevent heartworm disease, and to control ear mites (Otodectes cynotes) in cats and dogs. It is also approved for the treatment and control of sarcoptic mange (Sarcoptes scabiei) in dogs and hookworms (Ancylostoma tubaeformis) and roundworms (Toxocara cati) in cats.
Beschreibung
Selamectin is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. At 0.1 μg/ml, selamectin is reported to inhibit growth in an H. contortus larval development assay.
Verwenden
Selamectin is a topical parasiticide and also used as a veterinary antihelminithic agent on animals.
Verwenden
Selamectin is a semi-synthetic avermectin derivative prepared by selective hydrolysis and oximation of doramectin. Selamectin is a potent nematocide used for the treatment of endo- and exo- parasites of domestic animals, notably cats and dogs. Like the other milbemycin/avermectins, selamectin selectively binds to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite.
Definition
ChEBI: Selamectin is a milbemycin.
Veterinary Drugs and Treatments
Topical selamectin (Revolution?—Pfizer) is indicated for flea infestations (Ctenocephalides felis), prevention of heartworm disease (Dirofilaria immitis), and for ear mites (Otodectes cynotis) in both dogs and cats. Additionally in dogs, it is indicated for sarcoptic mange (Sarcoptes scabeii), and tick infestations (Dermacentor variabilis). In cats: hookworm (Ancylostoma tubaeforme) and roundworm (Toxocara cati). The product (Revolution?) is labeled as not effective against either adult heartworms or clearing circulating microfilaria, but it possibly may have some efficacy with prolonged, continuous administration (Atkins 2007b).
Toxicity evaluation
Acute oral LD₅₀ for rats: >1,600 mg/kg

Selamectin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

220119-17-5, Selamectin Verwandte Suche:

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