α-Amanitin
Bezeichnung:α-Amanitin
CAS-Nr11030-71-0
Englisch Name:α-Amanitin
CBNumberCB0944238
SummenformelC39H53N9O14S
Molgewicht903.95502
MOL-Datei11030-71-0.mol
| Toxizität | A drug derived from the highly poisonous fungus Amanita phalloides (death cap). Alpha-amanitin, a cyclic octapeptide, is toxic because of its affinity for RNA polymerase II in eukaryotic cells. Since this enzyme is responsible for mRNA synthesis in the cell, the compound is a potent and selective inhibitor of mRNA synthesis. It is effective at concentrations below 1 μg/mL, and its specific action has made it useful in experimental biology. It is often used with actinomycin D to block RNA synthesis. |