3-(2-Methylphenoxy)-1,2-propandiol-1-carbamat

2-hydroxy-3-(o-tolyloxy)propyl carbamate Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Tolseram,Squibb,US,1954

• Definition

  ChEBI: Mephenesin carbamate is an aromatic ether.

• Manufacturing Process

  A solution of 32 g (0.30 mol) phosgene in 200 ml benzene is added dropwise at 30°C to a stirred solution of 53.5 g (0.32 mol) 3-o-toloxy-1,2-propanediol in 400 ml benzene. The mixture is stirred for an hour after the addition is completed, and a solution of 39 g of dimethylaniline in 100 ml benzene is then added, and stirring continued for a half-hour. Ice water (about one-third volume) is then added, and the benzene layer formed is separated and stirred with 500 mi concentrated ammonia at 5°C for six hours. The precipitated solid (weighing about 55 g) is recovered and recrystallized from water. The product thus obtained in a yield of about 53 g is 3-(o-toloxy)-2-hydroxypropyl carbamate: it is a crystalline solid melting at about 93°C, and having a lower water-solubility and higher oil-solubility than 3-o-toloxy-1,2-propanediol.

• Therapeutic Function

  Muscle relaxant

• Synthesis Reference(s)

  Journal of the American Chemical Society, 72, p. 3710, 1950 DOI: 10.1021/ja01164a107

2-hydroxy-3-(o-tolyloxy)propyl carbamate Upstream-Materialien And Downstream Produkte

3-(2-Methylphenoxy)-1,2-propandiol-1-carbamat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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