Octacosan-1-ol

Bezeichnung:Octacosan-1-ol

CAS-Nr557-61-9

Englisch Name:1-Octacosanol

CBNumberCB0783336

SummenformelC28H58O

Molgewicht410.76

MOL-Datei557-61-9.mol

Synonyma

Octacosan-1-ol

Octacosan-1-ol physikalisch-chemischer Eigenschaften

Schmelzpunkt	81-83°C
Siedepunkt	200-250°C
Dichte	0.8681 (rough estimate)
Brechungsindex	1.4559 (estimate)
storage temp.	2-8°C
Löslichkeit	Acetonitrile (Slightly, Heated), Benzene (Slightly, Heated), Chloroform (Slightly, Heated)
pka	15.20±0.10(Predicted)
Aggregatzustand	Crystalline Powder or Flaked Crystals
Farbe	White
Wasserlöslichkeit	<0.1 g/100 mL at 21.5 ºC
Merck	14,6744
Stabilität	Stable. Light-sensitive. Incompatible with strong oxidizing agents.
LogP	13.066 (est)
CAS Datenbank	557-61-9(CAS DataBase Reference)
NIST chemische Informationen	Octacosanol(557-61-9)
EPA chemische Informationen	1-Octacosanol (557-61-9)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22-36/37/38
S-Sätze:	22-24/25-37/39-26
WGK Germany	-
HS Code	29051990

Gefahreninformationscode (GHS)

1-Octacosanol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
white crystals or powder
Occurrence
Octacosanol is developed from wheat germ, sugar cane, or vegetable waxes.
Verwenden
A 28-carbon primary fatty alcohol commonly found in the epicuticular waxes of plants. It has shown protective effects against parkonsonism and due to its excellent tolerability and non-toxicity, octacosanol may be a promising agent for PD treatment.
Definition
ChEBI: A long-chain primary fatty alcohol that is octacosane in which a hydrogen attached to one of the terminal carbons is replaced by a hydroxy group.
benefits
1-octacosanol is a straight-chain aliphatic 28-carbon primary fatty alcohol used as a nutritional supplement. This high-molecular-weight organic compound is the main component of a natural product wax extracted from plants. 1-octacosanol is reported to possess cholesterol-lowering effects, antiaggregatory properties, cytoprotective use, and ergogenic properties. It has been studied as a potential therapeutic agent for treating Parkinson's disease.
Allgemeine Beschreibung
White crystalline powder.
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
1-Octacosanol is an alcohol. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.
Brandgefahr
Flash point data for 1-Octacosanol are not available; however, 1-Octacosanol is probably combustible.
Synthese
To a solution of octacos-11-en-1-ol (400 mg, 0.98 mmol) in THF (40 mL), 10% of Pd on charcoal (50 mg) was added and poured into a Parr reactor. The reduction was carried out at 80 ℃ and 35 bar H2 under stirring for 4 h. Similar results were achieved when the reaction was performed in a special US reactor (21.2 kHz) that works under pressure (Danacamerini – Torino); the reaction was carried out at 40 ℃ and 6 bar H2 for 3 h. In both cases, after filtration on a celite pad and evaporation under vacuum, a crude product was purified by flash chromatography using hexane: ethyl acetate 19: 1 as eluent. 1-Octacosanol was obtained as a white powder (358 mg, 89% yield)[1].
läuterung methode
Recrystallise it from large volumes of Me2CO. Sublime it at 200-250o/1mm instead of distilling it. [Beilstein 2 IV 1318.]
Einzelnachweise
[1] Giancarlo Cravotto. “Synthesis of 1-octacosanol and GC-C-IRMS discrimination of samples from different origin.” Natural Product Research 24 5 (2010): 428–39.

1-Octacosanol Upstream-Materialien And Downstream Produkte

Octacosan-1-ol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

557-61-9, 1-Octacosanol Verwandte Suche:

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