1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamid

Bezeichnung:1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamid

CAS-Nr35920-39-9

Englisch Name:NECA

CBNumberCB0763077

SummenformelC12H16N6O4

Molgewicht308.29

MOL-Datei35920-39-9.mol

Synonyma

1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamid

1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamid physikalisch-chemischer Eigenschaften

Schmelzpunkt	229-231°C
Dichte	1.87±0.1 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL Solutions may be stored for several days at 4°C.
pka	12.93±0.70(Predicted)
Aggregatzustand	powder
Farbe	white
Stabilität	Hygroscopic
InChIKey	JADDQZYHOWSFJD-FLNNQWSLSA-N
CAS Datenbank	35920-39-9

Sicherheit

Kennzeichnung gefährlicher	T+
R-Sätze:	28
S-Sätze:	22-26-36-45
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS-Nr.	VJ2232000
HazardClass	6.1(a)
PackingGroup	I
HS Code	29349990

Gefahreninformationscode (GHS)

NECA Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R28:Sehr giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
White Solid
Verwenden
5′-(N-Ethylcarboxamido)adenosine has been used:
- for the purification of human adenosine A_2Areceptor (A_2AR) in decylmaltoside (DM)
- to determine nonspecific binding of adenosine receptors
- to investigate adenosine 2B receptor (RA2B) mechanism of action by competition assay
Verwenden
Potent adenosine receptor agonist with some affinity at A1 and A2 receptors
Verwenden
A potent adenosine receptor agonist. Inhibits platelet aggregation and is centrally active in vivo
Definition
ChEBI: A derivative of adenosine in which the 5'-hydroxymethyl group is replaced by an N-ethylcarboxamido group.
Allgemeine Beschreibung
A cell-permeable adenosine analog that acts a potent non-selective agonist of adenosine receptors (K_i = 14 nM, 20 nM, 2.4 μM and 6.2 nM for A₁, A_2A, A_2B, A₃, respectively). Increases intracellular cAMP production (EC₅₀ = 3.1 μM in A_2B expressing CHO cells). Shown to increase glucagon release in a dose-dependent manner and inhibit insulin release at low concentrations. Although at higher concentration some insulin release is observed. Also, displays a wide range adenosine-dependent effects, such as blocking platelet aggregation and inhibiting DNA synthesis. When administered at reperfusion, it is shown reduce infarction and block the formation of the mitochondrial permeability transition pore by activating p70S6 kinase.
Biologische Aktivität
Potent adenosine receptor agonist (K i values are 14, 20 and 6.2 nM for human A 1 , A 2A and A 3 receptors respectively; EC 50 = 2.4 μ M for human A 2B ). Inhibits platelet aggregation and is centrally active in vivo .
Biochem/physiol Actions
Reversible: yes
Lager
Store at +4°C

1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuranuronamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

35920-39-9, NECA Verwandte Suche:

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