8-Aminoisoquinoline

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P271：Nur im Freien oder in gut belüfteten Räumen verwenden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

8-Aminoisoquinoline Chemische Eigenschaften,Einsatz,Produktion Methoden

• Chemische Eigenschaften

  Brown solid

• Verwenden

  8-Aminoisoquinoline and its derivatives are used as intermediates for antimalarial drugs in the pharmaceutical field. For example, their structure is similar to the antimalarial drug primaquine.

• Synthese

  

  63927-23-1

  

  23687-27-6

  General procedure for the synthesis of 8-aminoisoquinolines from 5-bromo-8-nitroisoquinolines: 5-bromo-8-nitroisoquinolines (1.00 g, 3.95 mmol) were dissolved in methanol (70 mL), and hydrogenation was carried out by adding palladium/activated charcoal (10% Pd, 200 mg) as a catalyst for 18 hr at room temperature and atmospheric pressure. Upon completion of the reaction, the reaction mixture was filtered through Celite to remove the catalyst. The filtrate was concentrated and purified by column chromatography (eluent: ethyl acetate/heptane) to afford the target compound 8-aminoisoquinoline (100 mg, 18% yield) as a greenish-brown solid.1H NMR (DMSO-d6, 400 MHz) δ 9.43 (s, 1H), 8.32 (d, 1H), 7.54 (d, 1H), 7.40 (dd, 1H) , 6.99 (d, 1H), 6.72 (d, 1H), 6.22 (s, 2H).

• Einzelnachweise

  [1] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 4, p. 803 - 806
  [2] Journal of Medicinal Chemistry, 2005, vol. 48, # 3, p. 744 - 752
  [3] Patent: WO2009/130481, 2009, A1. Location in patent: Page/Page column 143
  [4] Journal of Medicinal Chemistry, 2005, vol. 48, # 15, p. 4972 - 4982
  [5] Patent: WO2006/32851, 2006, A1. Location in patent: Page/Page column 49

8-Aminoisoquinoline Upstream-Materialien And Downstream Produkte

8-Aminoisoquinoline Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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