RO 20-1724 Struktur

RO 20-1724

Bezeichnung:RO 20-1724

CAS-Nr29925-17-5

Englisch Name:RO 20-1724

CBNumberCB0710844

SummenformelC15H22N2O3

Molgewicht278.35

MOL-Datei29925-17-5.mol

RO 20-1724 physikalisch-chemischer Eigenschaften

Siedepunkt	483.8±25.0 °C(Predicted)
Dichte	1.099±0.06 g/cm3(Predicted)
storage temp.	room temp
Löslichkeit	ethanol: 7 mg/mL
Aggregatzustand	solid
pka	14.54±0.40(Predicted)
Farbe	White
Biologische Quelle	synthetic (organic)
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months.
CAS Datenbank	29925-17-5(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3

Gefahreninformationscode (GHS)

RO 20-1724 Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
RO 20-1724 (29925-17-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 0.2 μM. Displays anti-inflammatory activity. Cell permeable
Verwenden
Ro 20-1724 Is an inhibitor of phosphodiesterase-4, and also very effective for patients with plaque psoriasis. Selective inhibitor of cAMP-specific phosphodiesterase. Selective PDE4 inhibitor.
Verwenden
Ro 20-1724 is a cell-permeable, cAMP-specific phosphodiesterase type IV (PDE4) inhibitor (IC50 = 2 μM). It weakly inhibits PDE3 with a Ki value greater than 25 μM. Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species. It is often used to study cAMP-related functions in vascular cells.
Definition
ChEBI: 4-[(3-butoxy-4-methoxyphenyl)methyl]-2-imidazolidinone is a member of methoxybenzenes.
Biologische Aktivität
Widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC 50 = 2.0 μ M). Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .
Biochem/physiol Actions
Inhibitor of cAMP phosphodiesterase. IC50 33 μM in vascular smooth muscle of the aorta.
Lager
Store at RT
Einzelnachweise
1) Soderling et al. (1998), Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase; Proc. Natl. Acad. Sci. USA, 95 8991 2) Nicholson et al. (1991), Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes; Trends Pharmacol. Sci., 12 19

RO 20-1724 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

29925-17-5, RO 20-1724 Verwandte Suche:

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