Magnesium-2-propylvalerat

Bezeichnung:Magnesium-2-propylvalerat

Englisch Name:MAGNESIUM DIPROPYLACETATE HYDRATE

CBNumberCB0692818

SummenformelC16H30MgO4

Molgewicht310.71

Synonyma

Magnesium-2-propylvalerat

Magnesium-2-propylvalerat physikalisch-chemischer Eigenschaften

Schmelzpunkt	>294°C (dec.)
storage temp.	Refrigerator
Löslichkeit	Ethyl Acetate (Slightly), Methanol (Slightly), Water (Slightly)
Aggregatzustand	Solid
Farbe	White
CAS Datenbank	62959-43-7

Gefahreninformationscode (GHS)

Verwenden
Magnesium Valproate is an anticonvulsant agent and the effects it exerts are the result of valproic acid and magnesium acting in a complementary way. Magnesium valproate is effective as monotherapy in patients with newly diagnosed or previously treated partial or generalised epilepsy.
Verwenden
Magnesium Valproate is an anticonvulsant agent and the effects it exerts are the result of valproic acid and magnesium acting in a complementary way. Magnesium valproate is effective as monotherapy in patients with newly diagnosed or previously treated partial or generalised epilepsy.
Verwenden
Antiepileptic
Handelsname
Logical (Armstrong)
Sicherheitsprofil
Moderately toxic by ingestion. Danger: A spontaneously combustible solid. When heated to decomposition it emits toxic vapors of magnesium.
Synthese
Diethyl malonate is alkylated with 1-bromopropane and then hydrolyzed and decarboxylated to afford Magnesium valproate.
Beschreibung
Valproic acid and its salt Magnesium Valproate is major antiepileptic drugs for the treatment of absence, myoclonic, and generalized tonic – clonic seizures and also may be effective against complex partial seizures. The most cited mechanisms are the increase in GABA function and the blockade of voltage-dependent Na+-channels. The most common side effects are gastrointestinal disturbances and sedation. The most serious adverse effect is liver damage, although this is rare. Teratogenic effects, predominantly spina bifida, are reported frequently.