2-(2,7-Dichlor-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoesure

Bezeichnung:2-(2,7-Dichlor-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoesure

CAS-Nr76-54-0

Englisch Name:2',7'-Dichlorofluorescein

CBNumberCB0690319

SummenformelC20H10Cl2O5

Molgewicht401.2

MOL-Datei76-54-0.mol

Synonyma

2-(2,7-Dichlor-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoesure

2-(2,7-Dichlor-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoesure physikalisch-chemischer Eigenschaften

Schmelzpunkt	280 °C (dec.)(lit.)
Siedepunkt	514.77°C (rough estimate)
Dichte	0.79 g/mL at 20 °C
Brechungsindex	1.5300 (estimate)
Flammpunkt	12°C (53.6°F)
storage temp.	room temp
Löslichkeit	alcohol: passes test
pka	4.46(at 25℃)
Aggregatzustand	crystalline
Farbe	orange to red-brown, powder
Säure-Base-Indikators(pH-Indikatoren)	4.0 (colorless) - 6.6 (green)
Wasserlöslichkeit	Soluble in ethanol and methanol. Slightly dimethyl sulfoxide. Insoluble in water.
maximale Wellenlänge (λmax)	509nm
BRN	58009
Stabilität	Stable. Incompatible with strong oxidizing agents.
Major Application	Electroluminescent devices, sol-gel silica films, integrated circuits, photoresists, lithographic printing plates, recording material, LED devices, photoconductors, Solid-state dye laser, lithographic printing plates, inks, Fluorescent pH sensors, emissive probes, chemotherapeutic treatment of disease, phototherapeutic treatment of disease, photodynamic treatment of disease
InChIKey	NZVMJBGGAQSNLI-UHFFFAOYSA-N
CAS Datenbank	76-54-0(CAS DataBase Reference)
EPA chemische Informationen	Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 2',7'-dichloro-3',6'-dihydroxy- (76-54-0)

Sicherheit

Kennzeichnung gefährlicher	Xi,F
R-Sätze:	36/37/38-36-67-11
S-Sätze:	26-36-16
RIDADR	UN 1219 3/PG 2
WGK Germany	3
RTECS-Nr.	NT8050000
TSCA	Yes
HS Code	3204 19 00

Gefahreninformationscode (GHS)

2',7'-Dichlorofluorescein Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R36:Reizt die Augen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
red to yellow solid
Verwenden
2',7'-Dichlorofluorescein is used as an indicator and as a cellular antioxidant activity. It is also used for the determination of carbohydrates and hydrogen peroxide by fluorescence densitometry and chemiluminescence respectively. It is used as an indicator for argentometry by Fajans method. It is also involved in the cellular antioxidant activity assay. It is utilized as an additive in fluorescence and laser studies.
A new fluorescent sensor for Cd2+ and its application in living cells imaging. Tetrahedron Lett. 2015, 56 (11), 1322-1327.
Colorimetric and fluorogenic signaling of fluoride ions by thiophosphinated dichlorofluorescein. Dyes Pigm. 2015, 112, 170-175.
Verwenden
Widely used probe, e.g. for determination of carbohydrates by fluorescence densitometry after TLC and determination of H2O2 by chemiluminescence. Fluorescent additives used in indirect fluorimetric detection in OTC-HPLC.
Verwenden
2',7'-Dichlorofluorescein is used as an indicator and as a cellular antioxidant activity. It is also used for the determination of carbohydrates and hydrogen peroxide by fluorescence densitometry and chemiluminescence respectively. It is used as an indicator for argentometry by Fajans method. It is also involved in the cellular antioxidant activity assay. It is utilized as an additive in fluorescence and laser studies.
Definition
2',7'-dichlorofluorescein is a member of 2-benzofurans. It has a role as a fluorochrome. It derives from a fluorescin.
Application
2',7'-dichlorofluorescein has been used as an oxidation-sensitive fluorescent probe to measure ROS (reactive oxygen species) formation in cells.
Biologische Aktivität
2',7'-dichlorofluorescein is an oxidation-sensitive fluorescent probe. 2′7′-dichlorofluorescein diacetate is oxidized to 2′7′-dichlorofluorescein in the presence of ROS (reactive oxygen species).
Biochem/physiol Actions
2′,7′-Dichlorofluorescein is an oxidation-sensitive fluorescent probe. 2′7′-dichlorofluorescein diacetate is oxidized to 2′7′-dichlorofluorescein in the presence of ROS (reactive oxygen species).
Einzelnachweise
[1] Chander Hans. “2’,7’-Dichlorofluorescein (DCF) or 2’,7’-dichlorodihydrofluorescein diacetate (DCFH2-DA) to measure reactive oxygen species in erythrocytes.” Biomedicine & Pharmacotherapy (2021): 111512.

2',7'-Dichlorofluorescein Upstream-Materialien And Downstream Produkte

2-(2,7-Dichlor-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoesure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

76-54-0, 2',7'-Dichlorofluorescein Verwandte Suche:

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