2,2-Dimethylbuttersure

Bezeichnung:2,2-Dimethylbuttersure

CAS-Nr595-37-9

Englisch Name:2,2-Dimethylbutyric acid

CBNumberCB0675444

SummenformelC6H12O2

Molgewicht116.16

MOL-Datei595-37-9.mol

Synonyma

2,2-Dimethylbuttersure

2,2-Dimethylbuttersure physikalisch-chemischer Eigenschaften

Schmelzpunkt	-14°C
Siedepunkt	94-96 °C/5 mmHg (lit.)
Dichte	0.928 g/mL at 25 °C (lit.)
Brechungsindex	n20/D 1.4154(lit.)
Flammpunkt	175 °F
storage temp.	Refrigerator
Löslichkeit	Chloroform (Sparingly), Methanol (Slightly)
pka	pK1:5.03 (18°C)
Aggregatzustand	Liquid
Farbe	Clear colorless to pale yellow
Wichte	0.928
Decomposition	176-178 ºC
BRN	1720666
InChIKey	VUAXHMVRKOTJKP-UHFFFAOYSA-N
LogP	1-2.3 at 20℃ and pH2.5-6.7
CAS Datenbank	595-37-9(CAS DataBase Reference)
NIST chemische Informationen	Butanoic acid, 2,2-dimethyl-(595-37-9)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36/37-36
RIDADR	3265
WGK Germany	3
HazardClass	8
PackingGroup	III
HS Code	29156000

Gefahreninformationscode (GHS)

2,2-Dimethylbutyric acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
2,2-Dimethylbutyric acid is the intermediate of crucial importance in producing cardiovascular drugs, such as Simvastatin and agricultural chemicals, miticide spiral shell mite ester. It can also be used for rubber, dyestuff, etc. industries simultaneously. All 2,2-Dimethylbutyric acid production processes are that primary isoamyl alcohol and formic acid react under sulfuric acid catalysis. This technique's shortcoming is to produce a large amount of Waste Sulfuric Acids.
Chemische Eigenschaften
Colorless to light yellow or light green liquid
Verwenden
2,2-Dimethylbutyrate (DMB) is a potential treatment for thalassemia and hemoglobinopathies.
Definition
ChEBI: A branched-chain fatty acid and metabolite of the lactone prodrug simvastatin, whose sodium salt is potentially useful for the treatment of thalassaemias and haemoglobinopathies.
Synthesis Reference(s)
Synthetic Communications, 19, p. 1945, 1989 DOI: 10.1080/00397918908052587
Synthese
Adding 15 to 25 parts by weight of solid acid catalyst, 150 to 170 parts by weight of isoamyl alcohol, and 15 to 20 parts by weight of sulfuric acid into a high-pressure reactor, evenly stirring to obtain a reaction mixture, introducing nitrogen gas into the reactor, introducing CO into the reaction mixture at a temperature of 85 to 90 ℃, maintaining a pressure of 0.1 to 0.15 MPa until the pressure starts to rise; cooling to the room temperature, introducing nitrogen gas into the reactor to replace the CO gas, discharging materials from the reactor, filtering to obtain the solid acidified catalyst; adding 5 to 15 parts by weight of saturated sodium chloride water solution into the filtrate, evenly stirring, allowing the system to stand still, removing the lower water layer, and rectifying the upper oil layer to obtain the product 2,2-Dimethylbutyric acid.

2,2-Dimethylbutyric acid Upstream-Materialien And Downstream Produkte

2,2-Dimethylbuttersure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

595-37-9, 2,2-Dimethylbutyric acid Verwandte Suche:

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