Phenylpyropene A

Phenylpyropene A Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Phenylpyropene A is a fungal metabolite originally isolated from P. griseofulvum that has enzyme inhibitory and insecticidal activities.^1,2,3 It inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC₅₀ = 0.8 μM).¹ Phenylpyropene A inhibits diacylglycerol acyltransferase (DGAT) in rat liver microsomes (IC₅₀ = 78.7 μM). It induces mortality in 100% of M. persicae when used at a concentration of 5 ppm.³

• Einzelnachweise

  1. Kwon, O.E., Rho, M.C., Song, H.Y., et al. Phenylpyropene A and B, new inhibitors of acyl-CoA: Cholesterol acyltransferase produced by Penicillium griseofulvum F1959 J. Antibiot. (Tokyo) 55(11),1004-1008(2002).
  2. Lee, S.W., Rho, M.C., Choi, J.H., et al. Inhibition of diacylglycerol acyltransferase by phenylpyropenes produced by Penicillium griseofulvum F1959 J. Microbiol. Biotechnol. 18(11),1785-1788(2008).
  3. Horikoshi, R., Goto, K., Mitomi, M., et al. Identification of pyripyropene A as a promising insecticidal compound in a microbial metabolite screening J. Antibiot. (Tokyo) 70(3),272-276(2017).

Phenylpyropene A Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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