PIVMECILLINAM HYDROCHLORIDE

PIVMECILLINAM HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  Pivmecillinam is an orally active prodrug of Amdinocillin (A576300), an broad spectrum penicillin antibiotic that binds specifically to penicillin binding protein 2.

• Clinical Use

  Antibacterial agent

• Arzneimittelwechselwirkung

  Potentially hazardous interactions with other drugs
  Antiepileptics: avoid concomitant use with valproate.
  Methotrexate: penicillins can reduce the excretion of methotrexate (increased risk of toxicity).
  Probenecid: reduces excretion of penicillins.

• Stoffwechsel

  Pivmecillinam is rapidly hydrolysed to mecillinam which is the active drug, plus pivalic acid and formaldehyde. About 45% of a dose may be excreted in the urine as mecillinam, mainly within the first 6 hours. Mecillinam is partly excreted with bile, giving rise to biliary concentrations about 3 times the serum levels.

PIVMECILLINAM HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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