PKI 166 hydrochloride

PKI 166 hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  PKI-166 hydrochloride is a potent, selective, and orally bioactive EGFR tyrosine kinase inhibitor with IC50 of 0.7 nM.

• in vivo

  PKI-166 hydrochloride (100 mg/kg; po; daily; for 29 days) inhibits of pancreatic cancer growth.
  

  Animal Model: < /td>	Male athymic nude mice with L3.6pl cells xenograft (8-12 weeks)
  Dosage: < /td>	100 mg/kg
  Administration:	Oral administration; daily; for 29 days
  Result:	Significantly decreased median tumor volume.

• target

  IC50: 0.7 nM (EGFR tyrosine kinase)

• Lager

  Store at +4°C

PKI 166 hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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