Dibenzoylperoxid Produkt Beschreibung

Benzoyl peroxide Struktur
94-36-0
  • CAS-Nr.94-36-0
  • Bezeichnung:Dibenzoylperoxid
  • Englisch Name:Benzoyl peroxide
  • Synonyma:Dibenzoylperoxid;Benzoylsuperoxid
    G20;BPO;Cadet;Garox;Topex;Xerac;Oxy 5;oxy-5;Oxy-L;BZF-60
  • CBNumber:CB0484149
  • Summenformel:C14H10O4
  • Molgewicht:242.23
  • MOL-Datei:94-36-0.mol
Dibenzoylperoxid physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :105 °C(lit.)
  • Siedepunkt: :176°F
  • Dichte :1.16 g/mL at 25 °C(lit.)
  • Brechungsindex :1.5430 (estimate)
  • Flammpunkt: :>230 °F
  • storage temp.  :2-8°C
  • Löslichkeit :0.35mg/l
  • Aggregatzustand :powder
  • Farbe :White
  • Wasserlöslichkeit :Insoluble
  • Merck  :14,1116
  • BRN  :984320
  • Expositionsgrenzwerte :TLV-TWA 5 mg/m3; IDLH 7000 mg/m3.
  • Stabilität: :Strong oxidizer. Highly flammable. Do not grind or subject to shock or friction. Incompatible with reducing agents, acids, bases, alcohols, metals, organic materials. Contact with combustible material, heating or friction may cause fire or explosion.
  • InChIKey :OMPJBNCRMGITSC-UHFFFAOYSA-N
  • CAS Datenbank :94-36-0(CAS DataBase Reference)
  • NIST chemische Informationen :Benzoyl peroxide(94-36-0)
  • EPA chemische Informationen :Peroxide, dibenzoyl(94-36-0)
Sicherheit

Benzoyl peroxide Chemische Eigenschaften,Einsatz,Produktion Methoden

  • ERSCHEINUNGSBILD WEISSE KRISTALLE ODER PULVER.
  • ARBEITSPLATZGRENZWERTE TLV: 5 mg/m?(als TWA) Krebskategorie A4 (nicht klassifizierbar als krebserzeugend für den Menschen); (ACGIH 2005).
    MAK: 5 mg/m?(Einatembare Fraktion); Spitzenbegrenzung: überschreitungsfaktor I(1); (DFG 2005).
  • AUFNAHMEWEGE Aufnahme in den Körper durch Inhalation des Aerosols.
  • INHALATIONSGEFAHREN Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch beim Dispergieren schnell erreicht werden, vor allem als Pulver.
  • WIRKUNGEN BEI KURZZEITEXPOSITION WIRKUNGEN BEI KURZZEITEXPOSITION:
    Die Substanz reizt die Augen, die Haut und die Atemwege.
  • WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION Wiederholter oder andauernder Kontakt kann zu Hautsensibilisierung führen.
  • LECKAGE Gefahrenbereich verlassen bei großen Mengen verschütteten Materials! Zündquellen entfernen. Reste mit viel Wasser wegspülen. NICHT mit Sägemehl oder anderen brennbaren Absorptionsmitteln binden.
  • R-Sätze Betriebsanweisung: R8:Feuergefahr bei Berührung mit brennbaren Stoffen.
    R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
    R43:Sensibilisierung durch Hautkontakt möglich.
    R36:Reizt die Augen.
    R2:Durch Schlag, Reibung, Feuer oder andere Zündquellen explosionsgefährlich.
    R7:Kann Brand verursachen.
    R1:In trockenem Zustand explosionsgefährlich.
    R51/53:Giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
    R21/22:Gesundheitsschädlich bei Berührung mit der Haut und beim Verschlucken.
    R62:Kann möglicherweise die Fortpflanzungsfähigkeit beeinträchtigen.
    R50:Sehr giftig für Wasserorganismen.
    R61:Kann das Kind im Mutterleib schädigen.
  • S-Sätze Betriebsanweisung: S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
    S17:Von brennbaren Stoffen fernhalten.
    S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
    S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
    S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
    S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
    S3/7:Behälter dicht geschlossen halten und an einem kühlen Ort aufbewahren.
    S14:Von . . . fernhalten (inkompatible Substanzen sind vom Hersteller anzugeben).
    S47:Nicht bei Temperaturen über . . . °C aufbewahren (vom Hersteller anzugeben).
    S35:Abfälle und Behälter müssen in gesicherter Weise beseitigt werden.
    S7:Behälter dicht geschlossen halten.
    S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
  • Chemische Eigenschaften white powder or crystals
  • Chemische Eigenschaften Benzoyl peroxide is an odorless, white or colorless crystalline powder.
  • Verwenden benzoyl peroxide is an antibacterial ingredient commonly used in acne treatments. It functions by forcing an oxidant (peroxide in this case) into the philosebaceous orifice where it releases oxygen, thereby diminishing the P. acnes population. This reduces the level of free fatty acids and skin infection. Benzoyl peroxide may cause skin irritation in people with sensitive skin.
  • Verwenden Benzoyl Peroxide is a colorless, crystalline solid with a faint odor of benzaldehyde resulting from the interaction of benzoyl chloride and a cooled sodium peroxide solution. it is insoluble in water. it is used in specified cheeses at 0.0002% of milk level. it is used for the bleaching of flour, slowly decomposing to exert its full bleaching action, which results in whiter flour and bread.
  • Verwenden Benzoyl peroxide is used as a source offree radicals in many organic syntheses andto initiate polymerizations of styrene, vinylchloride, vinyl acetate, and acrylics; to curethermoset polyester resins and silicone rubbers;in medicine for treating acne; and forbleaching vegetable oil, cheese, flour, and fats.
  • Verwenden vitamin B complex
  • Verwenden Benzoyl Peroxide is a widely used organic compound of the peroxide family. Benzoyl Peroxide is often used in acne treatments , bleaching and polymerizing polyester and many other uses.
  • Verwenden Source of free radicals for industrial processes. Oxidizing agent in bleaching oils, flour, etc.; catalyst in the plastics industry; initiator in polymerization.
  • Indications Benzoyl peroxide is a potent oxidizing agent that has both antimicrobial and comedolytic properties; its primary use is in treating acne vulgaris. It is converted in the skin to benzoic acid; clearance of absorbed drug is rapid, and no systemic toxicity has been observed. The major toxicities are irritation and contact allergy. Outgrowth of bacteria resistant to topical antibiotics used to treat acne can be reduced by the addition of benzoyl peroxide in combination products such as erythromycin (Benzamycin) and clindamycin (Benzaclin).
  • Trademarks Acne-Aid Cream (Stiefel); Benoxyl (Stiefel); Benzac (Galderma); Benzac W (Galderma); Brevoxyl (Stiefel); Clear By Design (SmithKline Beecham); Dry and Clear (Whitehall-Robins); Epi-Clear (Bristol-Myers Squibb); Fostex BPO Bar, Gel, and Wash (Bristol-Myers Products); Loroxide (Dermik); PanOxyl (Stiefel); Persa-Gel (Ortho Pharmaceutical); Vanoxide (Dermik);Altex.
  • Weltgesundheitsorganisation (WHO) Benzoyl peroxide slowly releases oxygen and hence is bactericidal. It is also keratolytic, antiseborrheic and irritant. It is used in the treatment of acne. Benzoyl peroxide is listed in the WHO Model List of Essential Drugs.
  • Allgemeine Beschreibung White, odorless powder, moderately toxic.
  • Air & Water Reaktionen Insoluble in water.
  • Reaktivität anzeigen Benzoyl peroxide reacts exothermically withstrong acids, strong bases, amines, reducingagents, and sulfur compounds. Explosionshave been reported when it reacted withcarbon tetrachloride and ethylene (Bolt andJoyce 1947), lithium aluminum hydride(Sutton 1951), N,N-dimethyl aniline (Hornerand Betzel 1953), hot chloroform (NFPA1986), and methyl methacrylate (NFPA1986). Lappin (1948) reported an explosionwhen a bottle was opened. Organic matterentrapped in the threads of the bottleprobably reacted explosively with benzoylperoxide.
  • Hazard Highly toxic via inhalation. May explode spontaneously when dry (<1% of water). Never mix unless at least 33% water is present. Skin and upper respiratory tract irritant. Questionable carcinogen.
  • Health Hazard The health hazard from benzoyl peroxideis low. It can cause irritation of the skin,mucous membranes, and eyes. An intraperitonealinjection of 250 mg/kg was lethal toadult mice. Systemic toxicity in humans isnot known. It may be mild to moderatelytoxic on an acute basis. The oral LD50 valuein rats is 7710 mg/kg (NIOSH 1986). Itstoxicity from inhalation is low; an LC50 valueof 700 ppm in mice is suggested (ACGIH1986).
    Benzoyl peroxide may cause gene damageand DNA inhibition. It has been foundto cause skin tumor. The evidence of its carcinogenicityin animals and humans is inadequate.
  • Brandgefahr Benzoyl peroxide can cause a major fire and explosion hazard. It is highly flammable and a strong oxidizer; autoignition temperature 80°C (176°F). It ignites instantly. The rate and violence of decomposition and the potential ease of such ignition or decomposition have been experimentally measured by Noller et al. (1964). Lead pipe deformation (LPD), pressure vessel test (PVT), and self-accelerating decomposition test (SADT) have been performed to measure these explosive characteristics. Heating 5 g of benzoyl peroxide in an aluminum tester containing an aperture vent and 6-atm rupture disk, caused the disk to blow up in 95 seconds when the aperture vent area was less than 174.7 mm2. Redried material was more violent. The decomposition hazard was greatly reduced with wet and diluted benzoyl peroxide.
    Noller et al. (1964) measured the SADT temperature at 82.2°C (180°F), above which the decomposition was self-accelerating, sudden, and produced smoke.
    Benzoyl peroxide is a deflagrant, posing a severe explosion hazard. The compound is sensitive to heavy shock, such as impact or blows, as well as to friction and heat. Especially in the dry state, it is highly dangerous.
    A water sprinkler should be used to extinguish fires. Water should be used to keep the containers cool.
  • Kontakt-Allergie Benzoyl peroxide is an oxidizing agent widely employed in acne topical therapy. It is also used as a polymerization catalyst of dental or industrial plastics and as a decolorizing agent of flours, oils, fats, and waxes. Irritant or allergic dermatitis may affect workers in the electronics and plastics (epoxy resins and catalysts) industries, electricians, ceramic workers, dentists and dental technicians, laboratory technicians, bakers, and acne patients. As it was contained in candles, it also induced contact dermatitis in a sacristan. Patch tests may be irritant.
  • mögliche Exposition Used as polymerization initiator, curing agent, and cross-linking agent.
  • Veterinary Drugs and Treatments Benzoyl peroxide products are used topically either as gels or in shampoos. Shampoos are generally used for seborrheas, greasy skin (seborrhea oleosa), or crusty pyodermas (such as seborrheic dermatitis/pyoderma commonly seen in Cocker Spaniels). Gels may be useful for treating recurrent localized skin infections (e.g., chin acne), localized Demodex lesions, superficial and deep pyodermas (adjunctive therapy), seborrhea oleosa, and Schnauzer comedo syndrome. Benzoyl peroxide possesses antimicrobial (especially antibacterial), keratolytic and antiseborrheic actions. It also is It has some mild antipruritic activity and wound healing effects, and is thought to increase follicular flushing. Benzoyl peroxide’s antimicrobial activity is due to the oxidative benzoyl peroxy radicals formed that disrupt cell membranes.
  • Lager Benzoyl peroxide should be stored in acool and well-ventilated area, isolated fromother chemicals and free of heating andelectrical installations. Dry compound maybe shipped in polyethylene-lined paper bagsor fiber containers packed in wooden boxeso.
  • Versand/Shipping UN3104 : Organic peroxide type C, solid, Hazard Class: 5.2; Labels: 5.2—Organic peroxide, Technical Name Required. UN3108 : Organic peroxide type E, solid, Hazard Class: 5.2; Labels: 5.2—Organic peroxide, Technical
  • läuterung methode Dissolve benzoyl peroxide in CHCl3 at room temperature and precipitate it by adding an equal volume of MeOH or pet ether. Similarly it is precipitated from acetone by adding two volumes of distilled water. It has also been crystallised from 50% MeOH and from diethyl ether. Dry it under vacuum at room temperature for 24hours. Store it in a desiccator in the dark at 0o. When purifying in the absence of water it can be EXPLOSIVE, and operations should be done on a very small scale with adequate protection. Large amounts should be kept moist with water and stored in a refrigerator. [Kim et al. J Org Chem 52 3691 1987, Beilstein 9 IV 777.]
  • Inkompatibilitäten May explode when heated above melting point, 103 C. A strong oxidizer. Extremely explosionsensitive to heat, shock, friction, and concussion. May explode or cause fire on contact with reducing agents; combustible substances, organic substances, wood, paper, metal powders, lithium aluminum hydride. Violent reaction with alcohols, organic and inorganic acids, and amines.
  • Waste disposal Pretreatment involves decomposition with sodium hydroxide. The final solution of sodium benzoate, which is very biodegradable, may be flushed into the drain. Disposal of large quantities of solution may require pH adjustment before release into the sewer or controlled incineration after mixing with a noncombustible material.
Benzoyl peroxide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Dibenzoylperoxid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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94-36-0, Benzoyl peroxide Verwandte Suche:
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