Clopamid

Bezeichnung:Clopamid

CAS-Nr636-54-4

Englisch Name:Clopamide

CBNumberCB0469173

SummenformelC14H20ClN3O3S

Molgewicht345.84

MOL-Datei636-54-4.mol

Synonyma

Clopamid

Clopamid physikalisch-chemischer Eigenschaften

Schmelzpunkt	248-249℃
Dichte	1.39±0.1 g/cm3(Predicted)
RTECS-Nr.	CV2338875
storage temp.	2-8°C
Löslichkeit	Chloroform (Slightly, Heated, Sonicated), Methanol (Slightly)
Aggregatzustand	Solid
pka	9.41±0.60(Predicted)
Farbe	Pale Yellow to Light Yellow
CAS Datenbank	636-54-4(CAS DataBase Reference)
EPA chemische Informationen	Benzamide, 3-(aminosulfonyl)-4-chloro-N-[(2R,6S)-2,6-dimethyl-1-piperidinyl]-, rel- (636-54-4)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	42/43
S-Sätze:	36
WGK Germany	3

Gefahreninformationscode (GHS)

Clopamide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White or almost white, hygroscopic, crystalline powder
Originator
Brinaldix,Novartis
Verwenden
Clopamide is a thiazide-like diuretic that inhibits sodium/chloride cotransporters in the proximal convoluted tubule of the kidney, which prevents the reabsorption of sodium and chloride. This compound is intended for research purposes only.
Verwenden
Antihypertensor;Gonad stimuling agent
Verwenden
Antihypertensive; diuretic.
Definition
ChEBI: 4-chloro-N-[(2S,6R)-2,6-dimethyl-1-piperidinyl]-3-sulfamoylbenzamide is a sulfonamide.
Manufacturing Process
To a solution of 5.5 g of 3-chlorsulfonyl-4-chlorobenzoylchloride in 20 ml chlorobenzole 3.3 g of 1-amino-cis-2,6-dimethylpiperidin-hydrochloride slowly was added at room temperature. Reaction mixture was heated to 100°-105°C during 8 h, then it was cooled to room temperature. The precipitated crystals of N-[cis-2,6-dimethyl-piperidyl-(1)]-3-chlorsulfonyl-4-chlorobenzoylamide were filtered and dried at 100°C under vacuo, then was treated by ammonium at room temperature. The obtained product was chromatographed (aluminum oxide; eluent: chloroform-methanol 9:1 and methanol-ether) to give N-[cis- 2,6-dimethylpiperidyl-(1)]-3-sulfamyl-4-chlorbenzoylamide, melting point 235°-237°C.
Trademarks
Aquex (Novartis).
Therapeutic Function
Diuretic, Antihypertensive

Clopamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

636-54-4, Clopamide Verwandte Suche:

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