11-DEOXY-11-METHYLENE PROSTAGLANDIN D2

Gefahreninformationscode (GHS)

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• Alarmwort

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11-DEOXY-11-METHYLENE PROSTAGLANDIN D2 Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  Prostaglandin D2 (PGD2; ) is one of the five primary enzymatic prostaglandins derived directly from PGH2 . PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, leukocyte-type PGD synthase. 11-deoxy-11-methylene PGD2 is a novel, chemically stable, isosteric analog of PGD2 wherein the 11-keto group is replaced by an exocyclic methylene. In the PGE series, the analogous modification leads to a stable, somewhat less potent agonist which embodies the same uterine stimulant and cervical ripening activities as the parent prostaglandin. However, 11-deoxy-11-methylene PGD2 has been reported by one group to be essentially without agonist activity on human platelets, a DP1 receptor assay.

• Definition

  ChEBI: 11-deoxy-11-methylene-PGD2 is a prostanoid.

11-DEOXY-11-METHYLENE PROSTAGLANDIN D2 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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