3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE

Bezeichnung:3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE

CAS-Nr1005-24-9

Englisch Name:3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE

CBNumberCB0431956

SummenformelC7H9ClN2O

Molgewicht172.61

MOL-Datei1005-24-9.mol

3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE physikalisch-chemischer Eigenschaften

Schmelzpunkt	207-209℃ (water acetone )
storage temp.	room temp
Löslichkeit	H2O: soluble15mg/mL, clear
Aggregatzustand	crystalline
Farbe	white
Wasserlöslichkeit	almost transparency
Merck	14,9693
CAS Datenbank	1005-24-9(CAS DataBase Reference)

Sicherheit

WGK Germany	3
RTECS-Nr.	UU1925000
HS Code	2933.39.9200

Gefahreninformationscode (GHS)

3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; ). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.
Verwenden
Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; ). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.
Verwenden
1-Methylnicotinamide chloride may be used as a standard in the quantification of 1-methylnicotinamide in urine samples using ion pairing reverse-phase high performance liquid chromatography (RP-HPLC).
Allgemeine Beschreibung
1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT) and exhibits antithrombotic and anti-inflammatory effects.
Biochem/physiol Actions
1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT). 1-Methylnicotinamide (MNA) has been shown to have antithrombotic and anti-inflammatory effects. A recent study indicated that MNA may exert antithrombotic and anti-inflammatory effects through direct action on the endothelium, with a vasorelaxing effect by enhancement of NO bioavailability and reduction of eNOS-dependent oxidative stress. Enhanced NNMT activity is a feature of many types of cancer. How much direct involvement MNA has in the tumorigenesis associated with overexpression of NNMT is under investigation. MNA by itself increased mitochondrial Complex I activity and increased cancer cell viability in SH-SY5Y neuroblastoma cells that do not produce NNMT.
läuterung methode
Recrystallise it from MeOH. [Beilstein 22 III/IV 468, 22/2 V 80.]

3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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