1-Methyl-4-pyrazole boronic acid pinacol ester

Bezeichnung:1-Methyl-4-pyrazole boronic acid pinacol ester

CAS-Nr761446-44-0

Englisch Name:1-Methyl-4-pyrazole boronic acid pinacol ester

CBNumberCB0414153

SummenformelC10H17BN2O2

Molgewicht208.07

MOL-Datei761446-44-0.mol

1-Methyl-4-pyrazole boronic acid pinacol ester physikalisch-chemischer Eigenschaften

Schmelzpunkt	59-64 °C(lit.)
Siedepunkt	308.3±15.0 °C(Predicted)
Dichte	1.05±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	Chloroform (slightly), Methanol (Slightly)
pka	2.09±0.10(Predicted)
Aggregatzustand	Crystals
Farbe	Off-white to yellow
Wasserlöslichkeit	Slightly soluble in water.
InChI	InChI=1S/C10H17BN2O2/c1-9(2)10(3,4)15-11(14-9)8-6-12-13(5)7-8/h6-7H,1-5H3
InChIKey	UCNGGGYMLHAMJG-UHFFFAOYSA-N
SMILES	N1(C)C=C(B2OC(C)(C)C(C)(C)O2)C=N1
CAS Datenbank	761446-44-0(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn,F,Xi
R-Sätze:	22-36/37/38
S-Sätze:	26-36-37/39
WGK Germany	3
Hazard Note	Irritant/Flammable
TSCA	No
HazardClass	IRRITANT
HS Code	29349990

Gefahreninformationscode (GHS)

1-Methyl-4-pyrazole boronic acid pinacol ester Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
White to light yellow crystal powde
Verwenden
suzuki reaction
Verwenden
1-Methyl-4-pyrazole boronic acid pinacol ester is a reagent used for Suzuki-Miyaura cross-coupling reactions, transesterification reactions. It is involved in several reactions as a reagent for the preparation of aminothiazoles as γ-secretase modulators,amino-pyrido-indol-carboxamides, as potential JAK2 inhibitors for myeloproliferative disorders therapy, pyridine derivatives as TGF-β1 and active A signaling inhibitors and MK-2461 analogs as inhibitors of c-Met kinase for the treatment of cancer.
Synthese
To the solution of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (0.40 g, 2.06 mmol) in THF (10 mL) was added NaH (0.1.00 g, 4.12 mmol) followed by methyl iodide (0.25 mL, 4.12 mmol) at 0° C and the reaction mixture was stirred at ambient temperature for 4 hr. The reaction was quenched with saturated NH4Cl solution (20 mL) and extracted with ethyl acetate (2 x 50 mL). The combined organic layers were washed with brine (20 mL), dried over sodium sulfate, and distilled under reduced pressure to obtain 1-Methyl-4-pyrazole boronic acid pinacol ester.

1-Methyl-4-pyrazole boronic acid pinacol ester Upstream-Materialien And Downstream Produkte

1-Methyl-4-pyrazole boronic acid pinacol ester Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

761446-44-0, 1-Methyl-4-pyrazole boronic acid pinacol ester Verwandte Suche:

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