Triammonium-5,5'-(3-carboxylato-4-oxocyclohexa-2,5-dienylidenmethylen)disalicylat

Bezeichnung:Triammonium-5,5'-(3-carboxylato-4-oxocyclohexa-2,5-dienylidenmethylen)disalicylat

CAS-Nr569-58-4

Englisch Name:Aluminon

CBNumberCB0413969

SummenformelC22H17NO9

Molgewicht439.38

MOL-Datei569-58-4.mol

Synonyma

Triammonium-5,5'-(3-carboxylato-4-oxocyclohexa-2,5-dienylidenmethylen)disalicylat

Triammonium-5,5'-(3-carboxylato-4-oxocyclohexa-2,5-dienylidenmethylen)disalicylat physikalisch-chemischer Eigenschaften

Schmelzpunkt	220-225 °C (dec.)(lit.)
Siedepunkt	573.92°C (rough estimate)
Dichte	1.4414 (rough estimate)
Brechungsindex	1.6300 (estimate)
storage temp.	room temp
Löslichkeit	DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): 100 μg/ml
Colour Index	43810
Aggregatzustand	powder
Farbe	Deep red
PH	5.3 (10g/l, H2O, 20°C)
Wasserlöslichkeit	800 g/L (20 ºC)
Merck	14,322
BRN	3900820
Stabilität	Stable.
CAS Datenbank	569-58-4
EPA chemische Informationen	Benzoic acid, 5-[(3-carboxy-4-hydroxyphenyl)(3-carboxy-4-oxo-2,5-cyclohexadien-1-ylidene)methyl]-2-hydroxy-, triammonium salt (569-58-4)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/38-36/37/38
S-Sätze:	26-36-37/39
WGK Germany	2
RTECS-Nr.	GU4800000
TSCA	Yes
HS Code	29189090
Toxizität	LD50 orally in Rabbit: 9000 mg/kg

Gefahreninformationscode (GHS)

Aluminon Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/38:Reizt die Augen und die Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
dark red crystalline powder
Verwenden
Aluminon can used as a reagent for aluminum in solution. It is also Forms brilliantly colored lakes with aluminum, chromium, iron, beryllium. Generally used for the detection and colorimetric estimation of aluminum in water, foods, tissues. Cf. Scherrer, Mogerman, J. Res. Natl. Bur. Stand. 21, 105 (1938).
Verwenden
It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types.
Definition
ChEBI: An ammonium salt that is the ammonium salt of 3,3'-[(3-carboxy-4-oxocyclohexa-2,5-dien-1-ylidene)methylene]bis(6-hydroxybenzoic acid). A dye commonly used to detect the presence of the aluminium ion in an aqueous solution.
Biochem/physiol Actions
Aurintricarboxylic acid readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types. Its neuroprotective effect, perhaps due to its ability to prevent down-regulation of Ca2+ impermeable GluR2 receptors or to its ability to inhibit calpain, a Ca2+-activated protease that is activated during apoptosis.
Sicherheitsprofil
Human reproductive effects by ingestion: changes in male fertility. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NH3 and NOx,.

Aluminon Upstream-Materialien And Downstream Produkte

Triammonium-5,5'-(3-carboxylato-4-oxocyclohexa-2,5-dienylidenmethylen)disalicylat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

569-58-4, Aluminon Verwandte Suche:

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