2,2,6-Trimethyl-4H-1,3-dioxin-4-on

Bezeichnung:2,2,6-Trimethyl-4H-1,3-dioxin-4-on

CAS-Nr5394-63-8

Englisch Name:2,2,6-Trimethyl-4H-1,3-dioxin-4-one

CBNumberCB0412977

SummenformelC7H10O3

Molgewicht142.15

MOL-Datei5394-63-8.mol

Synonyma

2,2,6-Trimethyl-4H-1,3-dioxin-4-on

2,2,6-Trimethyl-4H-1,3-dioxin-4-on physikalisch-chemischer Eigenschaften

Schmelzpunkt	12-13 °C(lit.)
Siedepunkt	~275 °C(lit.)
Dichte	1.07 g/mL at 25 °C(lit.)
Brechungsindex	n20/D 1.460(lit.)
Flammpunkt	67 °F
storage temp.	2-8°C
Löslichkeit	water: insoluble
Aggregatzustand	Liquid
Farbe	Dark brown
Wasserlöslichkeit	practically insoluble
BRN	2408
Expositionsgrenzwerte	ACGIH: TWA 250 ppm; STEL 500 ppm OSHA: TWA 1000 ppm(2400 mg/m3) NIOSH: IDLH 2500 ppm; TWA 250 ppm(590 mg/m3)
InChIKey	XFRBXZCBOYNMJP-UHFFFAOYSA-N
CAS Datenbank	5394-63-8(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	F,Xi
R-Sätze:	11-36/37/38-36
S-Sätze:	16-26-27-36/37/39-9-33
RIDADR	UN 1993 3/PG 2
WGK Germany	3
HazardClass	3
PackingGroup	II
HS Code	29329995

Gefahreninformationscode (GHS)

2,2,6-Trimethyl-4H-1,3-dioxin-4-one Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R11:Leichtentzündlich.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R36:Reizt die Augen.
S-Sätze Betriebsanweisung:
S16:Von Zündquellen fernhalten - Nicht rauchen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S27:Beschmutzte, getränkte Kleidung sofort ausziehen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S9:Behälter an einem gut gelüfteten Ort aufbewahren.
S33:Maßnahmen gegen elektrostatische Aufladungen treffen.
Chemische Eigenschaften
Dark brown liquid
Verwenden
Diketene-Acetone Adduct can be used in place of diketene in many reactions. As a transportable form of diketene, it is especially important in those countries, where the transportation of diketene is not allowed or at least not desired.
Verwenden
2,2,6-Trimethyl-1,3-dioxin-4-one is used in the synthesis of dihydropyrimininones as picomolar sodium iodide symporter inhibitors. It is also used in the synthesis of resorcinol amide Hsp90 Inhibitor AT13387. It is used in the synthesis of acetylketene by flash pyrolysis.
Application
2,2,6-Trimethyl-4H-1,3-dioxin-4-one generates unstable acetylketene together with acetone when heated above 120 ℃. Subsequent condensation with isocyanates, arylcyanates, or substituted cyanamides gives access to a wide range of 1,3-oxazine derivatives. Furthermore, diketene – acetone adduct can also be used for the preparation of a variety of compounds that are not accessible from diketene.
Chemische Reaktivität
Diketene – acetone adduct (2,2,6-Trimethyl-4H-1,3-dioxin-4-one) can be regarded as a stabilized form of diketene. It can be safely transported and may conveniently be used instead of diketene in many reactions. For example, it reacts with alcohols and amines to yield acetoacetates and acetoacetamides, respectively. Diketene – acetone adduct generates unstable acetylketene together with acetone when heated above 120 ?C. Subsequent condensation with isocyanates, arylcyanates, or substituted cyanamides gives access to a wide range of 1,3-oxazine derivatives. Furthermore, diketene – acetone adduct can also be used for the preparation of a variety of compounds that are not accessible from diketene.

2,2,6-Trimethyl-4H-1,3-dioxin-4-one Upstream-Materialien And Downstream Produkte

2,2,6-Trimethyl-4H-1,3-dioxin-4-on Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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